Monoclonal antibody directed against CD11c antigen detects presence of macrophages, mononuclear phagocytes, hairy cell leukaemia cells and various activated T cells and neutrophils.
| Inventor | Institute |
|---|---|
| Nancy Hogg | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151044 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology;Cell signaling and signal transduction;Immunology;Stem cell biology |
| Application: | FACS ; IHC ; IF ; IP ; Fn |
| Target: | Integrin alpha X (CD11c; gp150/95 a subunit) |
| Reactivity: | Human |
| Clone: | 3.9 |
| Host: | Mouse |
| Class: | Monoclonal |
| Primary citation: | Hogg et al. 1986. Eur J Immunol. 16(3):240-8. PMID: 3456894. |
| Alternate name: | CD11 antigen-like family member C, Leu M5, Leukocyte adhesion glycoprotein p15,95 alpha chain, Leukocyte adhesion receptor p15,95, CD antigen: CD11c |
|---|---|
| Product description: | Monoclonal antibody directed against CD11c antigen detects presence of macrophages, mononuclear phagocytes, hairy cell leukaemia cells and various activated T cells and neutrophils. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 150 kDa |
| Immunogen: | Rheumatoid synovial fluid cells and fibronectin purified human monocytes |
| Immunogen Uniprot ID: | P20702 |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | Anti-CD11c (integrin aX) was created to understand the expression of the integrin aX molecule and to look at the heterogeneity of tissue macrophages. Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells and aberrant integrin expression has been found in many epithelial tumours. Integrin alpha X is found on hairy cell leukaemia's, malignant histiocytes, on tissue macrophages, monocytes, activated neutrophils and some T-cell clones. It is a member of the LFA-1 CR3 family of human leukocyte differentiation antigens. This antibody binds to CD11c glycoprotein which helps mediate cellular adhesion and cell-matrix adhesion such as fibronectin. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | Store at -20° C frozen. Avoid repeated freeze / thaw cycles |
| Shipping conditions: | Dry ice |
| References: |
Langer et al. 2019. Elife. 8:. PMID: 30717826. Dos Reis et al. 2019. Front Immunol. 10:1291. PMID: 31244842. Hunegnaw et al. 2019. Front Immunol. 10:1537. PMID: 31333668. Muir et al. 2018. J Leukoc Biol. 103(4):615-628. PMID: 29493813. Silveira et al. 2017. J Immunol. 199(3):1003-1011. PMID: 28667164. Locci et al. 2016. Nat Immunol. :. PMID: 27376469. Activin A programs the differentiation of human TFH cells. Gbel et al. 2016. Nat Commun. 7:11626. PMID: 27188843. Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells. Expression of death receptor 3 on peripheral blood mononuclear cells differes in adult IBD patients and children with newly diagnosed IBD. Dendritic Cell-Secreted Cytotoxic T-Lymphocyte-Associated Protein-4 Regulates the T-cell Response by Downmodulating Bystander Surface B7. Slebioda et al. 2016. Cytometry B Clin Cytom. :. PMID: 27001939. Halpert et al. 2016. Stem Cells Dev. :. PMID: 26979751. Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation. rning et al. 2016. J Control Release. :. PMID: 26993426. Swindle et al. 2015. Immunology. 146(3):470-85. PMID: 26288256. Increased proportions of dendritic cells and recovery of IFN? responses in HIV/HCV co-infected patients receiving ART. Saraswati et al. 2015. Hum Immunol. :. PMID: 26455474. Interferon-? enhances both the anti-bacterial and the pro-inflammatory response of human mast cells to Staphylococcus aureus. Petvises et al. 2015. Cell Mol Immunol. :. PMID: 25891217. Delineation of a novel dendritic-like subset in human spleen. Nausch et al. 2015. PLoS Negl Trop Dis. 9(3):e0003627. PMID: 25799270. Group 2 innate lymphoid cell proportions are diminished in young helminth infected children and restored by curative anti-helminthic treatment. Jawhara et al. 2012. J Immunol. 189(5):2468-77. PMID: 22844116. Integrin aX?2 is a leukocyte receptor for Candida albicans and is essential for protection against fungal infections. McMichael AJ et al. (Ed) 1997. Leucocyte Typing III. ISBN 13 9780192615527 Hogg et al. 1986. Eur J Immunol. 16(3):240-8. PMID: 3456894. The p150,95 molecule is a marker of human mononuclear phagocytes: comparison with expression of class II molecules. |
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