Cat. #151790
Anti-CD11C [118/A5] mAb
Cat. #: 151790
Unit size: 100 ug
Availability: 3-4 weeks
Target: CD11C, Integrin, alpha X (complement component 3 receptor 4 subunit). ITGAX
Class: Monoclonal
Application: IHC
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Jacqueline Cordell
Institute: University of Oxford
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-CD11C [118/A5] mAb
- Research fields: Cell biology;Cell signaling and signal transduction;Immunology;Stem cell biology
- Clone: 118/A5
- Class: Monoclonal
- Conjugation: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: IHC
- Description: The integrin alpha X chain protein (CD11c) belongs to the ?ĂÂ2 integrin subfamily. Integrins are cell surface receptors composed of a heterodimer containing an a and ?ĂÂ subunit. CD11c (the a subunit) combines with CD18 (the ?ĂÂ subunit) to form the leukocyte specific integrin inactivated-C3b receptor 41,2. CD11c is known to be expressed on monocytes/macrophages, granulocytes, activated B cells, in spleen and in bone marrow.
- Immunogen: Synthetic peptide conjugated to KLH corresponding to the C terminus of human CD11C: ANGQIAPENGTQTPSPPSEK
- Isotype: IgG2b
- Myeloma used: NS0
- Recommended controls: Human tonsil
Target Details
- Target: CD11C, Integrin, alpha X (complement component 3 receptor 4 subunit). ITGAX
- Target background: The integrin alpha X chain protein (CD11c) belongs to the ?ĂÂ2 integrin subfamily. Integrins are cell surface receptors composed of a heterodimer containing an a and ?ĂÂ subunit. CD11c (the a subunit) combines with CD18 (the ?ĂÂ subunit) to form the leukocyte specific integrin inactivated-C3b receptor 41,2. CD11c is known to be expressed on monocytes/macrophages, granulocytes, activated B cells, in spleen and in bone marrow.
Applications
- Application: IHC
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Dry ice
References
- Ihanus et al. 2007. Blood. 109(2):802-10. PMID: 16985175.
- Red-cell ICAM-4 is a ligand for the monocyte/macrophage integrin CD11c/CD18: characterization of the binding sites on ICAM-4.
- Ammon et al. 2000. Immunology. 100(3):364-9. PMID: 10929059.
- Comparative analysis of integrin expression on monocyte-derived macrophages and monocyte-derived dendritic cells.
- Bilsland et al. 1994. J Immunol. 152(9):4582-9. PMID: 7512600.
- The leukocyte integrin p150,95 (CD11c/CD18) as a receptor for iC3b. Activation by a heterologous beta subunit and localization of a ligand recognition site to the I domain.
- Myones et al. 1988. J Clin Invest. 82(2):640-51. PMID: 2969921.
- Neutrophil and monocyte cell surface p150,95 has iC3b-receptor (CR4) activity resembling CR3.
