Anti-C3 [WM1]

After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.

Contributors

Inventor Institute
Walter Bodmer Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Cat. #: 153253
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Biochemistry;Cell biology;Immunology;Neurobiology
Application: Fn ; IP
Target: Human complement component 3
Reactivity: Human
Clone: WM1
Host: Mouse
Class: Monoclonal
Product description: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
Conjugation: Unconjugated
Isotype: IgG1 lambda
Immunogen: Human complement component 3
Myeloma used: P3X63Ag8
Target background: C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
Format: Liquid
Shipping conditions: Dry ice
References:

Whitehead et al. 1981. Eur J Immunol. 11(2):140-6. PMID: 6163641.

A monoclonal antibody against human complement component C3: the production of C3 by human cells in vitro.

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