Anti-BCL2 [bcl-2/100] mAb

Cat. #151406

Anti-BCL2 [bcl-2/100] mAb

Cat. #: 151406

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 1-2 weeks

Target: Bcl2

Class: Monoclonal

Application: IHC ; WB

Reactivity: Human

Host: Mouse


This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.


Inventor: Jacqueline Cordell

Institute: University of Oxford

Primary Citation: Pezzella et al. 1990. Lancet. 336(8729):1510-1. PMID: 197911

Tool Details
Target Details

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

  • Name: Anti-BCL2 [bcl-2/100] mAb
  • Research fields: Apoptosis and autophagy;Cancer;Cell signaling and signal transduction;Metabolism
  • Clone: bcl-2/100
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: IHC ; WB
  • Description: Monoclonal antibody directed against both isoforms of BCL-2 protein.
  • Immunogen: Synthetic peptide of amino acids 41-54 of human bcl-2 oncoprotein
  • Immunogen uniprot id: P10415
  • Isotype: IgG1
  • Myeloma used: P3/NS1/1-Ag4.1

Target Details

  • Target: Bcl2
  • Target background: The pro-survival protein BCL2 derives its name from B-cell lymphoma 2, as it is the second member of a range of proteins initially described in chromosomal translocations involving chromosomes 14 and 18 in follicular lymphomas. There are two isoforms, alpha and beta, of Bcl-2 have been identified and are a result of alternative splicing at the C-terminus. BCL-2 protein is involved in apoptosis, and inhibits the function of pro-apoptotic proteins such as Bax and Bak. Damage to the Bcl-2 gene has been identified as a cause of a number of cancers, including melanoma, breast, prostate, chronic lymphocytic leukaemia, and lung cancer, and a possible cause of schizophrenia and autoimmunity. It is also a cause of resistance to cancer treatments. This antibody recognises both the alpha and beta isoforms of BCL-2.


  • Application: IHC ; WB


  • Format: Liquid
  • Concentration: 8 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
  • Shipping conditions: Shipping at 4° C


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