peQE30-HisNter-TDP1-102 Vector

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Tool name: peQE30-HisNter-TDP1-102 Vector
• Alternate name: TARDBP, TAR DNA Binding Protein, TDP-43, TAR DNA-Binding Protein 43, ALS10
• Research fields: Genetics;Neurobiology;Microbiology
• Tool sub type: pQE30
• Backbone size without insert: 3461
• Bacterial resistance: Ampicillin
• Description: Concentration 1.2mg/ml
• Additional notes: The TAR DNA-binding protein (TDP-43) is a highly conserved heterogeneous nuclear ribonucleoprotein (hnRNP) that controls the transcription, splicing and RNA stability of specific genes. The protein associates with single-stranded RNA and DNA sequences, and exhibits remarkable specificity for UG/TG dinucleotide repeats. Regulation of the human low-molecular-weight neurofilament (hNFL) by TDP-43 has also been reported to occur through 3′ UTR recruitment. TDP-43 is the major protein in inclusions from patients suffering from frontotemporal lobar degeneration (FTLD) with ubiquitin-positive inclusions and amyotrophic lateral sclerosis (ALS). The N-terminal region of TDP-43 is a highly structured sequence that contributes to the reversible dimerization and oligomerization of this protein. It contains a bipartite Nuclear Localization Signal that ensures the predominant nuclear localization of TDP-43.

Target Details

• Target: TDP43 N-terminal domain 1-102

Application Details

• Application notes: Concentration 1.2mg/ml

References

• MompeĂĄn et al. 2016. FEBS J. 283(7):1242-60. PMID: 26756435.
• The TDP-43 N-terminal domain structure at high resolution.