#153937

Water-soluble monovalent copper ligand-2 (MCL-2)

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Cat. #153937

Water-soluble monovalent copper ligand-2 (MCL-2)

Cat. #: 153937

Sub-type: Inhibitor

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Application: determination of Cu(I) binding affinities of proteins and small-molecule ligands

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Contributor

Inventor: Christoph J. Fahrni

Institute: Georgia Institute Of Technology

Tool Details
Target Details
Application Details
References

Tool Details

*FOR RESEARCH USE ONLY

  • Tool name: Water-soluble monovalent copper ligand-2 (MCL-2)
  • Alternate name: MCL-2
  • Research fields: Drug development;Other
  • Tool sub type: Inhibitor
  • Primary target: Copper I; Cu(I)
  • Description: Copper is an essential trace element that is central to a broad range of biological processes, including cellular respiration, connective tissue formation, pigment synthesis, antioxidant defense, and photosynthesis in plants and bacteria. The measurement of reliable Cu(I) protein binding affinities requires competing reference ligands with similar binding strengths; however, the literature on such reference ligands is not only sparse but often conflicting. To address this deficiency, Dr. Fahr...
  • Application: determination of Cu(I) binding affinities of proteins and small-molecule ligands
  • Solubility: water

Target Details

  • Primary target: Copper I; Cu(I)

Application Details

  • Application: determination of Cu(I) binding affinities of proteins and small-molecule ligands

References

  • Bagchi et al. 2013. J Am Chem Soc. 135(49):18549-59. PMID: 24298878.
  • Robust affinity standards for Cu(I) biochemistry.