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Breast cancer has become a leading cause of cancer deaths among female cancer patients due to its high incidence. Consequently, it generates a considerable amount of research interest from scientists globally.
At CancerTools.org, we have curated an extensive collection of cell lines, antibodies and associated reagents, and made them available to scientists in pursuit of their groundbreaking breast cancer research towards understanding cancer cell biology, tumour-immunology, disease mechanisms, cancer genomics, drug design and discovery.
The collection is supporting cancer scientists to uncover new cancer pathways, develop in vitro cancer models and gain a better understanding of cancer.
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Cell lines
This collection features cell lines with key functions and high relevance in breast cancer research, including:
Anti-oestrogen resistant breast cancer cell lines
Derived from human breast cancer cell lines MCF-7 and T47D which depend on oestrogen for growth and demonstrate resistance to hormone-dependent breast cancer treatments, the anti-oestrogen resistant cell lines offer the potential for developing novel predictive biomarkers for therapy response and an improved understanding of the underlying molecular mechanisms of resistance, supporting new drug discovery.
Cell lines with recurrent chromosomal aneuploidies
Derived from mouse mammary glands, NCI-HPN-F cell lines demonstrate recurrent chromosomal aneuploidies enabling investigation and identification of tumourigenesis-related cancer-specific genes and signalling pathways.
Immortalised human breast epithelial cell lines
Immortalised using SV40, human breast epithelial cell lines are models to study differentiation and phenotypic transformation.
Organoids, media and mouse models
Antibodies
This collection features antibodies for targets with key functions and high relevance in breast cancer research, including:
Tumour suppressors
Tumour suppressors with key roles in biological processes across different types of tumours as well as those altered in a specific set of cancer types, such as breast, ovarian and pancreatic cancers.
Oncogenes
Oncogenes, such as c-MYC, a molecule of high interest in breast cancer research due to its regulation of key biological processes in the tumour microenvironment, e.g. angiogenesis, tumour evasion, invasion, and migration.
Tumour associated antigens
Tumour associated antigens, e.g., MUC1 which is aberrantly overexpressed in 90% of human breast cancer, thus representing a promising marker for breast cancer diagnosis and prognosis.