Caov-3 Cell Line Product
[…] CA-125, Ba-2, and Ca-1 tumour-associated antigens. The Caov-3 cells harbour a nonsense mutation in the p53 gene, and have multiple copies of the ovarian cancer oncogene PIK3CA. They are sensitive […]
Anti-deltaNp63 [deltaNp63-1.1] Product
[…] suppressor role and differentiate from the TA (TAp63) isoforms of the same protein. Binding specificity: within MLYLENNAQTQFSE. No cross-reaction with p53 or p73 isoforms. Specificity verified by CRISPR-knockout and shRNA knockdown.
Anti-deltaNp63 [PANp63-6.1] Product
[…] identified the epitope PSHLIR, which occurs twice within the central region of p63. The antibody recognizes TAp63 and deltaNp63. The antibody does not cross-react with p53 or any p73 isoform tested.
UM-UC-1 (Human bladder transitional cell carcinoma) cell line Product
[…] in diameter in < 3 weeks. UM-UC-1 showed strong over expression of nuclear staining for p53 by immunochemical analysis. UM-UC-1 was more resistant to adenoviral gene transduction than several of […]
UM-UC-3 (Human bladder transitional cell carcinoma) cell line Product
[…] produced tumours, 1-1.5 cm in diameter in < 3 weeks. UM-UC-3 has large deletions in T P53 and did not show p53 staining. This cell line was more resistant to adenoviral […]
BICR 78 Cell Line Product
[…] from a squamous cell carcinoma of the oral alveolus of a Caucasian male. Keratin and involucrin markers present. Known mutations: p53, p16 and p14ARF. Cells are not tumourigenic in athymic mice.
H357 Cell Line Product
[…] morphology, STNMP stage I, well differentiated and node negative tumour. This cell line has mutant p53, codon 110 exon 4, G to A; the previously reported mutant Ha-ras status of […]
Chk2 inhibitor CCT241533 Small Molecule (Tool Compound) Product
[…] colon cancer cells as well as a radioprotective effect in mouse thymocytes. In normal cells, p53 is activated by CHK2 and other kinases in response to double-strand DNA damage resulting […]
Anti-TIGAR [M2-P4H2] Product
TIGAR (T P53 (tumor protein 53)-induced glycolysis and apoptosis regulator), also known as C12orf5, is a 270 amino acid protein induced by the p53 tumor suppressor pathway that functions to […]
Anti-HHV-8 LNA-1 [LN53] Product
[…] interaction with a number of cellular proteins. These include transcriptional regulators and known tumour suppressors, p53 and retinoblastoma (RB). This nuclear protein is also involved in maintaining the latent state […]
