PDVC57B Cell Line Product

[…] a model of relapse after surgery. PDVC57B is syngeneic for C57B1/6 mice and carries a p53 mutation in codon 231, (ATG-GTC) and an A-T tranversion at cod 61 of the […]

HCT 116 p300 KO [F2] Cell Line Product

[…] HCT 116 p300 KO Cell Line is a tool for the in vitro study of p300 in colon carcinoma, and specifically of its role in p53-dependent apoptosis, cellular adhesion and migration.

Adapted from Wallace et al. 2015. PLoS Pathog. 11(3)

HCT 116 p300 KO [D10] Cell Line Product

[…] the in vitro study of p300 in colon carcinoma, and specifically of its role in p53-dependent apoptosis, cellular adhesion and migration. Cell lines available are p300 WT (HCT116), p300 KO […]

mRNA encoding either Xenopus ?-globin (x-?globin); Flag-tagged human Aven-WT or Flag-tagged Aven-NES282-292 were added to cycling Xenopus egg extracts to drive protein expression. Aliquots of extracts were then taken at the indicated times and immunoblotted with anti-phospho polo-like kinase-1 (pPlx; upper panels) and antiphospho Tyr15-Cdc2 (Cdc2 pY15; lower panels) antibodies. Adapted from Esmaili et al. 2010. Cell Cycle. 9(19)

Anti-Plx [AZ44] Product

[…] a mitotic regulator conserved from yeasts to humans. Many key cell cycle regulators such as p53, cdc25, cyclin B and the Anaphase Promoting Complex are directly targeted by Plx.The Anaphase […]

Anti-Plx [AZ27] Product

[…] (Plx) is a mitotic regulator conserved from yeasts to humans. Many key cell cycle regulators such as p53, cdc25, cyclin B and the Anaphase Promoting Complex are directly targeted by Plx.

Anti-Plx [AZ24] Product

[…] (Plx) is a mitotic regulator conserved from yeasts to humans. Many key cell cycle regulators such as p53, cdc25, cyclin B and the Anaphase Promoting Complex are directly targeted by Plx.

H376 Cell Line Product

[…] of a 40 year-old female patient. STNMP stage III, well differentiated, node positive tumour. Mutant p53, codon 266 exon 8, G to T; wild type K-, N-, and Ha-ras. This […]

Cell staining with SMP14 hybridoma supernatant of MCF7 treated with Nutlin

Anti-MDM2 [SMP14] Product

MDM2 is over-expressed in many tumours. Its principal function is the ubiquitination and degradation of p53 tumour suppressor protein.

Head and neck cancer Page

[…] a favourable indicator of prognosis in some subsets of HNC. As well as antibodies for p53 and EGFR, as overexpression of EGFR and inhibition of p53 are commonly observed in […]