Anti-HPV18E6 [C1X1] Product

[…] and E7 are the major viral oncoproteins that regulate cell proliferation through the inactivation of p53 and Rb1 tumour suppressor proteins respectively. BF7 can be used for detection of HPV […]

H314 Cell Line Product

[…] of an 82 year-old male patient. STNMP stage II, moderately differentiated, node positive tumour. Mutant p53, codon 176 exon 5, G to T and 373 exon 11, A to G; […]

Anti-JMY [HMY117] Product

[…] anti-JMY antibody recognises uman JMY. JMY is a p300-binding protein with dual action: by enhancing P53 transcription in the nucleus, it plays an important role in the cellular response to […]

Anti-HPV18E6 [C1N1] Product

[…] and E7 are the major viral oncoproteins that regulate cell proliferation through the inactivation of p53 and Rb1 tumour suppressor proteins respectively. BF7 can be used for detection of HPV […]

H157 Cell Line Product

[…] morphology, STNMP stage II, well differentiated and node positive tumour. This cell line has mutant p53, codon 306 exon 8, G to A; wild type K-, N- and Ha-ras. Cultured […]

Expression of MUC1 in non-neoplastic bladder urothelium; non-invasive papillary urothelial carcinoma; urothelial carcinoma in situ and invasive high grade urothelial carcinoma. Bladder tumor tissue sections or spots were probed with anti-MUC1 mAb (HMFG2) after non-specific blocking with horse serum. All sections were examined under microscope and the immunoreactivity was evaluated by reddish brown staining. Representative photomicrographs are shown for MUC1 stained non-neoplastic bladder urothelium (A&B); low-grade papillary carcinoma (C); bladder carcinoma in situ (D); and high grade invasive cancer (E&F). In normal bladder urothelium; MUC1 expression was restricted to umbrella cells (shown by arrowhead in panel A and the magnified inset) in majority of samples. In some samples; a sheath of MUC1 mucin was observed over urothelium (arrow in 1B). In low-grade papillary carcinoma; intense staining of MUC1 was observed on the luminal surface of the urothelium and lower intensity of staining was observed in the other layers of urothelium (C). In urothelial carcinoma in situ; MUC1 expression was observed in all the layers of urothelium; however; staining was comparatively stronger in cells closer to the luminal border (D). In invasive high grade urothelial carcinoma; MUC1 staining was observed in cells invading singly (E) or as small groups within the lamina propria (F). Taken from PLoS One. 2014 Mar 26;9(3)

Anti-MUC1 [HMFG2] Product

[…] is upregulated in the lactating breast and in carcinomas. MUC1 also is involved in tumour progression and transcription through regulation of p53. Anti-MUC1 can react with unglycosylated MUC1, and several glycoforms.

HCT 116 p300 KO Rescue Cell Line Product

[…] the in vitro study of p300 in colon carcinoma, and specifically of its role in p53-dependent apoptosis, cellular adhesion and migration. Cell lines available are p300 WT (HCT116), p300 KO […]

HCT 116 p300 KO [F5] Cell Line Product

[…] the in vitro study of p300 in colon carcinoma, and specifically of its role in p53-dependent apoptosis, cellular adhesion and migration. Cell lines available are p300 WT (HCT116), p300 KO […]

ELISA showing equivalence in performance between anti-MUC1; Recombinant [HMFG2] ("recombinant HMFG2") and Anti-MUC1 [HMFG2] ("purified HMFG2"). ELISA was performed on a 60mer peptide which consists of 3 tandem repeats of MUC1. The secondary anti-mouse antibody was HRP linked and the binding identified with a coloured substrate; O-phenylenediamine. Data kindly provided by Dr. Joy Burchell and Prof. Joyce Taylor-Papadimitriou

Anti-MUC1 [HMFG2] Product

[…] and in carcinomas. MUC1 also is involved in tumour progression and transcription through regulation of p53. This is a recombinant version of the anti-MUC1 antibody. Anti-MUC1 can react with unglycosylated […]