Anti-Plx [AZ27] Product
[…] (Plx) is a mitotic regulator conserved from yeasts to humans. Many key cell cycle regulators such as p53, cdc25, cyclin B and the Anaphase Promoting Complex are directly targeted by Plx.
Anti-Plx [AZ24] Product
[…] (Plx) is a mitotic regulator conserved from yeasts to humans. Many key cell cycle regulators such as p53, cdc25, cyclin B and the Anaphase Promoting Complex are directly targeted by Plx.
Anti-MDM2 [SMP14] Product
MDM2 is over-expressed in many tumours. Its principal function is the ubiquitination and degradation of p53 tumour suppressor protein.
Anti-CDKN2A/p14ARF [ARF 4C6/4] Product
p14ARF is associated with the regulation of p53 and MDM2 and is deleted or methylated in many human cancers.
Tumour Immunology Antibodies Page
[…] the immunosuppressive tumour microenvironment and tumour immune escape. These signalling pathways include STAT3, β-Catenin, PI3K/PTEN/AKT/mTOR, p53, NF-κB, RAS/RAF/MAPK, and KRAS/MYC. They can drive effective immunocyte exclusion and disfunction, as well […]
pBABE’s Creation and Legacy: A Vector System That Propelled Cancer Research Blog Post
[…] paper used pBABE to demonstrate how oncogenic RAS triggers premature cellular senescence through p16INK4a/Rb and p53/p21pathways6. This discovery established senescence as a critical tumour-suppressive barrier, reshaping our understanding of cellular […]
Lung cancer Page
[…] major therapeutic target. Additionally, we have antibodies targeting tumour suppressor genes, including a panel of p53 antibodies (DO-11, DO-12, DO-1, Pab 240 and Pab 246) to enable detection of p53 […]
Anti-deltaNp63 [PANp63-6.1] Product
[…] identified the epitope PSHLIR, which occurs twice within the central region of p63. The antibody recognizes TAp63 and deltaNp63. The antibody does not cross-react with p53 or any p73 isoform tested.
Anti-deltaNp63 [deltaNp63-1.1] Product
[…] suppressor role and differentiate from the TA (TAp63) isoforms of the same protein. Binding specificity: within MLYLENNAQTQFSE. No cross-reaction with p53 or p73 isoforms. Specificity verified by CRISPR-knockout and shRNA knockdown.
UM-UC-1 (Human bladder transitional cell carcinoma) cell line Product
[…] in diameter in < 3 weeks. UM-UC-1 showed strong over expression of nuclear staining for p53 by immunochemical analysis. UM-UC-1 was more resistant to adenoviral gene transduction than several of […]
