Tumour Immunology Antibodies Page

[…] the immunosuppressive tumour microenvironment and tumour immune escape. These signalling pathways include STAT3, β-Catenin, PI3K/PTEN/AKT/mTOR, p53, NF-κB, RAS/RAF/MAPK, and KRAS/MYC. They can drive effective immunocyte exclusion and disfunction, as well […]

Detection of Sufu; phosphorylated S352 Sufu and HA after immunoprecipitation of HA tagged Sufu Wild Type and Sufu S352A from HEK293T cells. The top panel (pSufu (S352)) was probed with anti-phospho-Sufu polyclonal antibody showing the anti-phospho-Sufu polyclonal antibody is specific and recognises only the phosphorylated form of Sufu but not a mutant where S352 is mutated to alanine. In the middle panel (Sufu); an anti-Sufu polyclonal antibody was used to probe and shows the anti-Sufu polyclonal antibody binds to either form of Sufu independent of the phosphorylation status. The bottom panel shows the same immunoprecipitation preparations probed with an anti-haemagglutinin (HA) antibody; this detects both proteins via their HA tag.

Anti-phospho-Sufu Product

[…] ubiquitous in adult tissues._x000D_ _x000D_ Heterozygous loss of Sufu, in conjunction with the loss of p53, leads to the development of medulloblastoma and rhabdomyosarcoma. Somatic Sufu mutations have been identified […]

BICR 3 Cell Line. Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC).

BICR 3 Cell Line Product

[…] cell carcinoma of the alveolus of a Caucasian female. Keratin and involucrin markers present. Known mutations: p53 and p16. Cells are tumourigenic in athymic mice. Epidermal Growth Factor Receptor (EGFR) present.

BICR 22 Cell Line. Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC)

BICR 22 Cell Line Product

[…] a lymph node metastasis squamous cell carcinoma of the tongue of a Caucasian male. Keratin and involucrin markers present. Known mutations: p53, p16 and p14ARF. Cells are tumourigenic in athymic mice.

BICR 18 Cell Line. 24 hours post plating. Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC).

BICR 18 Cell Line Product

[…] metastasis squamous cell carcinoma (SSC) of the larynx. Keratin and involucrin markers present. Known mutations: p53, p16 and p14ARF. Cells are tumourigenic in athymic mice. By short tandem repeat (STR)-PCR […]

BICR 10 Cell Line. Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC)

BICR 10 Cell Line Product

[…] from a recurrent squamous cell carcinoma of the buccal mucosa of a Caucasian female. Keratin and involucrin markers present. Known mutations: p53, p16 and p14ARF. Cells are tumourigenic in athymic mice.

H413 Cell Line. Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC), UK.

H413 Cell Line Product

[…] of a 53 year-old female patient. STNMP stage II, moderately differentiated, node negative tumour. Mutant p53, codon 68 exon 4, G to T; wild type K-, N- and Ha-ras. These […]

Capan-1 Cell line Product

[…] In addition, they have an oncogenic mutation in K-Ras (G12V) and an inactivating mutation in p53. These cells express elevated levels of the Epidermal Growth Factor Receptor (EGFR) and do […]

Capan-2 Cell line Product

[…] pancreatic cancer. The Capan-2 cells express mutant K-Ras (G12V) and elevated levels of the Epidermal Growth Factor Receptor (EGFR). In addition, they express wildtype p53 and normal levels of SMAD4 protein.

CAMA-1 Cell Line Product

[…] have an in-frame mutation in the E-cadherin gene, resulting in a truncated, non-functional protein. In addition, they have oncogenic mutations in PTEN and p53 and amplification of the cyclin D1 gene.