SDHB Floxed Mouse

Cat. #153295

SDHB Floxed Mouse

Cat. #: 153295

Sub-type: Mouse

Availability: 6-8 weeks

Disease: Cancer

Model: Transgenic

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.


Inventor: Eyal Gottlieb

Institute: Cancer Research UK, Glasgow: The Beatson Institute

Tool Details
Target Details
Related Tools

Tool Details


  • Tool name: SDHB Floxed Mouse
  • Alternate name: Succinate dehydrogenase, SDH, Succinate-coenzyme Q reductase, SQR
  • Research fields: Cancer;Drug development;Genetics;Metabolism
  • Tool sub type: Mouse
  • Disease: Cancer
  • Model: Transgenic
  • Conditional description: Exon 3 of the succinate dehydrogenase can be deleted upon Cre recombinase expression as this exon is flanked with lox P sequences
  • Description: Succinate dehydrogenase (SDH) is an enzyme complex found in the inner mitochondrial membrane of mammalian mitochondria and many bacterial cells. SDH is the only enzyme that participates in both the electron transport chain and citric acid cycle. The enzymatic function of SDH oxidises succinate to fumarate in the tricarboxylic acid cycle and loosing this function is associated with cancer formation.
  • Genetic background: Backcrossed 10 times into C57/BL6
  • Zygosity: Homozygous
  • Strain: C57BL/6


  • Shipping conditions: Embryo/Spermatoza- Dry Ice

Target Details

  • Target: Succinate dehydrogenase

Related Tools

  • Related tools: Sdhb -/- CL 5 Cell Line ; Sdhb -/- CL 7 Cell Line ; Sdhb fl/fl Cell Line


  • Cardaci et al. 2015. Nat Cell Biol. 17(10):1317-26. PMID: 26302408.
  • Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis.