SAR-22-097F mouse line

Mouse line with cysteine 75 of AEG-1 mutated to serine. AEG-1/MTDH; palmitoylation; NASH; HCC; mouse model

Contributors

Inventor Institute
Devanand Sarkar Virginia Commonwealth University
Cat. #: 161681
Cancer types: Carcinoma
Research Fields: Cancer
disease: Non-alcoholic fatty liver disease (NAFLD)
Model: Knock-In
Strain: C57BL/6/J
Phenotype: Unaffected litter size of AEG-1-C75S mice compared to WT adn overall showing milder and different phenotype compared to AEG-1-/- mice
Primary citation: Komaniecki et al. Biochemistry 62(2):543-553. PMID: 36548985
Product description: Mouse line with cysteine 75 of AEG-1 mutated to serine. AEG-1-C75S mice might be more prone to developing NASH and HCC which could help design new therapeutic strategies. Findings identify a novel role of AEG-1 palmitoylation regulating NASH and HCC thereby establishing the rationale for using inhibitors of AEG-1 depalmitoylating enzymes for the treatment of NASH and HCC.
Conditional: No
CRISPR: Yes
Genetic background: AEG-1-C75S mice were created in C57BL/6/J background. ATG-1-C75S heterozygotexheterozygote mating was performed to generate AEG-1-WT adn AEG-1-C75S littermates
Production details: Knock-in mice by CRISPR/Cas9 in which Cys75 of AEG-1 was mutated to Ser (AEG-1-C75S). AEG-1-C75S mice were created in C57BL/6/J background. ATG-1-C75S heterozygotexheterozygote mating was performed to generate AEG-1-WT adn AEG-1-C75S littermates
References:

Komaniecki et al. Biochemistry 62(2):543-553. PMID: 36548985

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