Oct1/2 Knock Out Mouse

Oct1/2 are polyspecific organic cation transporters in the liver, kidney, intestine, and other organs. Useful for studies of drug transport in the liver, intestine and kidneys. OCT1 and OCT2 determine renal secretion of small organic cations.

Contributors

Inventor Institute
Alfred Schinkel Netherlands Cancer Institute
Cat. #: 153874
Research Fields: Cancer;Cell signaling and signal transduction;Drug development
Target: Oct1 and Oct2
Model: Knock-Out
Zygosity: Homozygous
Alternate name: SLC22A1/2, Solute Carrier Family 22 Member 1/2, Organic Cation Transporter 1/2
Product description: Oct1/2 are polyspecific organic cation transporters in the liver, kidney, intestine, and other organs. They are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. Useful for studies of drug transport in the liver, intestine and kidneys. OCT1 and OCT2 determine renal secretion of small organic cations.
Conditional: No
Genetic background: The model was created through sequential targeting of the Slc22a1 and Slc22a2 genes in 129/Ola-derived E14 ES cells and injecting the targeted cells into C57BL/6 blastocysts. Resultant chimeras were backcrossed to FVB/N for seven generations
Production details: The model was created through sequential targeting of the Slc22a1 and Slc22a2 genes in 129/Ola-derived E14 ES cells and injecting the targeted cells into C57BL/6 blastocysts. Resultant chimeras were backcrossed to FVB/N for seven generations
Additional notes: Useful for studies of drug transport in the liver, intestine and kidneys. OCT1 and OCT2 determine renal secretion of small organic cations. The Oct1/2 mouse was developed in the laboratory of Alfred Schinkel of the Netherlands Cancer Institute
Shipping conditions: Embryo/Spermatoza- Dry Ice
References:

Jonker et al. 2003. Mol Cell Biol. 23(21):7902-8. PMID: 14560032.

Deficiency in the organic cation transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in mice abolishes renal secretion of organic cations.

Jonker et al. 2001. Mol Cell Biol. 21(16):5471-7. PMID: 11463829.

Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene.

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