Cat. #151555
MUC1 Mouse
Cat. #: 151555
Sub-type: Mouse
Availability: 8-10 weeks
Disease: Cancer
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Joyce Taylor-Papadimitriou ; Joy Burchell
Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Tool name: MUC1 Mouse
- Alternate name: ADMCKD, ADMCKD1, Breast carcinoma associated antigen DF3, Breast carcinoma-associated antigen DF3, CA 15-3, CA15 3, CA15 3 antigen, CA15.3, Cancer antigen 15-3, Carcinoma associated mucin, Carcinoma-associated mucin, CD 227, CD227
- Cancer: Adenocarcinoma
- Cancers detailed: Adenocarcinoma
- Research fields: Cancer;Cell biology;Cell signaling and signal transduction;Genetics
- Tool sub type: Mouse
- Disease: Cancer
- Conditional description: Genomic fragment containing complete MUC1 gene and promoter region, enabling tissue-specific MUC1 expression pattern.
- Description: Model for preclinical study of anti-MUC1 vaccines/immunotherapies;
- Genetic background: A linear genomic fragment, containing the MUC1 gene and promoter, was injected into fertilized embryos (various backgrounds), and implanted into pseudopregnant mice. Transgenic mice were identified by Southern blot, and maintained as homozygotes.
- Phenotype: Mice demonstrate tissue-specific PEM expression pattern and glycosylation analogous to that observed in human tissues.
- Zygosity: Homozygous
- Production details: A linear genomic fragment, containing the MUC1 gene and promoter, was injected into fertilized embryos (various backgrounds), and implanted into pseudopregnant mice. Transgenic mice were identified by Southern blot, and maintained as homozygotes.
- Additional notes: Mice demonstrate tissue-specific PEM expression pattern and glycosylation analogous to that observed in human tissues.
Handling
- Shipping conditions: Embryo/Spermatoza- Dry Ice
Target Details
- Target: Human MUC1 (mucin-like protein 1) / PEM (polymorphic epithelial mucin)
References
- Peat et al. 1992. Cancer Res. 52(7):1954-60. PMID: 1372533.
- Tissue-specific expression of a human polymorphic epithelial mucin (MUC1) in transgenic mice.
