MUC1 Mouse

Model for preclinical study of anti-MUC1 vaccines/immunotherapies; Mice demonstrate tissue-specific PEM expression pattern and glycosylation analogous to that observed in human tissues.

Contributors

Inventor Institute
Joyce Taylor-Papadimitriou ; Joy Burchell Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Cat. #: 151555
Cancer types: Adenocarcinoma
Research Fields: Cancer;Cell biology;Cell signaling and signal transduction;Genetics
Target: Human MUC1 (mucin-like protein 1) / PEM (polymorphic epithelial mucin)
disease: Cancer
Zygosity: Homozygous
Phenotype: Mice demonstrate tissue-specific PEM expression pattern and glycosylation analogous to that observed in human tissues.
Alternate name: ADMCKD, ADMCKD1, Breast carcinoma associated antigen DF3, Breast carcinoma-associated antigen DF3, CA 15-3, CA15 3, CA15 3 antigen, CA15.3, Cancer antigen 15-3, Carcinoma associated mucin, Carcinoma-associated mucin, CD 227, CD227
Product description: Model for preclinical study of anti-MUC1 vaccines/immunotherapies;
Conditional description: Genomic fragment containing complete MUC1 gene and promoter region, enabling tissue-specific MUC1 expression pattern.
Genetic background: A linear genomic fragment, containing the MUC1 gene and promoter, was injected into fertilized embryos (various backgrounds), and implanted into pseudopregnant mice. Transgenic mice were identified by Southern blot, and maintained as homozygotes.
Production details: A linear genomic fragment, containing the MUC1 gene and promoter, was injected into fertilized embryos (various backgrounds), and implanted into pseudopregnant mice. Transgenic mice were identified by Southern blot, and maintained as homozygotes.
Additional notes: Mice demonstrate tissue-specific PEM expression pattern and glycosylation analogous to that observed in human tissues.
Shipping conditions: Embryo/Spermatoza- Dry Ice
References:

Peat et al. 1992. Cancer Res. 52(7):1954-60. PMID: 1372533.

Tissue-specific expression of a human polymorphic epithelial mucin (MUC1) in transgenic mice.

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