#151565

K14dNb Mouse

Cat. #151565

K14dNb Mouse

Cat. #: 151565

Sub-type: Mouse

Availability: 6-8 weeks

Disease: Cancer

Model: Knock-Out

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Contributor

Inventor: Fiona Watt

Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details
Handling
Target Details

Tool Details

*FOR RESEARCH USE ONLY

  • Tool name: K14dNb Mouse
  • Cancer: Digestive/Gastrointestinal cancer;Skin cancer
  • Cancers detailed: Colorectal;Melanoma
  • Research fields: Cancer;Cell signaling and signal transduction;Genetics;Neurobiology;Stem cell biology;Tissue-specific biology
  • Tool sub type: Mouse
  • Disease: Cancer
  • Model: Knock-Out
  • Conditional: Yes
  • Conditional description: Conditional expression of deltaNbeta-cateninER under Keratin 14 promoter giving tissue-specific epidermal expression.
  • Description: In vivo study of beta-catenin activation in skin; model for hair growth & follicle formation;
  • Genetic background: A deltaNbeta-cateninER transgenic vector, containing an N-terminally truncated beta-catenin cDNA fused to the hormone-binding domain of a mutant mouse estragen receptor under the control of the keratin 14 promoter, was injected into fertilised CBA/C57BL6 ooctyes. Founders were backcrossed to establish transgenic lines.
  • Phenotype: Skin abnormalities (hair follicle);
  • Production details: A deltaNbeta-cateninER transgenic vector, containing an N-terminally truncated beta-catenin cDNA fused to the hormone-binding domain of a mutant mouse estragen receptor under the control of the keratin 14 promoter, was injected into fertilised CBA/C57BL6 ooctyes. Founders were backcrossed to establish transgenic lines.

Handling

  • Shipping conditions: Embryo/Spermatoza- Dry Ice

Target Details

  • Target: Beta-catenin N-terminal truncation (deltaNbeta-catenin) fused with estrogen receptor (ER)