Cat. #151565
K14dNb Mouse
Cat. #: 151565
Sub-type: Mouse
Availability: 8-10 weeks
Disease: Cancer
Model: Knock-Out
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Fiona Watt
Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Tool name: K14dNb Mouse
- Cancer: Digestive / Gastrointestinal cancer;Skin cancer
- Cancers detailed: Colorectal;Melanoma
- Research fields: Cancer;Cell signaling and signal transduction;Genetics;Neurobiology;Stem cell biology;Tissue-specific biology
- Tool sub type: Mouse
- Disease: Cancer
- Model: Knock-Out
- Conditional: Yes
- Conditional description: Conditional expression of deltaNbeta-cateninER under Keratin 14 promoter giving tissue-specific epidermal expression.
- Description: In vivo study of beta-catenin activation in skin; model for hair growth & follicle formation;
- Genetic background: A deltaNbeta-cateninER transgenic vector, containing an N-terminally truncated beta-catenin cDNA fused to the hormone-binding domain of a mutant mouse estragen receptor under the control of the keratin 14 promoter, was injected into fertilised CBA/C57BL6 ooctyes. Founders were backcrossed to establish transgenic lines.
- Phenotype: Skin abnormalities (hair follicle);
- Production details: A deltaNbeta-cateninER transgenic vector, containing an N-terminally truncated beta-catenin cDNA fused to the hormone-binding domain of a mutant mouse estragen receptor under the control of the keratin 14 promoter, was injected into fertilised CBA/C57BL6 ooctyes. Founders were backcrossed to establish transgenic lines.
Handling
- Shipping conditions: Embryo/Spermatoza- Dry Ice
Target Details
- Target: Beta-catenin N-terminal truncation (deltaNbeta-catenin) fused with estrogen receptor (ER)
