HRN Nude Mouse

This mouse has a conditional deletion of POR and may be used in the drug development process to establish role of P450 activity in anti-cancer drug efficacy in vivo.

Contributors

Inventor Institute
Roland Wolf ; Colin Henderson University of Dundee
Cat. #: 151829
Research Fields: Cancer;Drug development;Genetics;Metabolism
Target: P450 Oxidoreductase
Product description: A P450 Oxidoreductase hepatic null in nude background (ICRF nude mouse). This mouse has a conditional deletion of POR and may be used in the drug development process to establish role of P450 activity in anti-cancer drug efficacy in vivo.
Conditional: Yes
Genetic background: The hepatic reductase null (HRN) line, which is PORlox/lox::CreALB, was crossed to the ICRF nude mouse. The ultimate experimental mouse is thus PORlox/lox::CreALB::nu/nu, with PORlox/lox::nu/nu as matched controls (the latter are essentially 'ordinary' nude mice, with normal POR expression, and thus normal hepatic P450 activity).
Production details: The hepatic reductase null (HRN) line, which is PORlox/lox::CreALB, was crossed to the ICRF nude mouse. The ultimate experimental mouse is thus PORlox/lox::CreALB::nu/nu, with PORlox/lox::nu/nu as matched controls (the latter are essentially 'ordinary' nude mice, with normal POR expression, and thus normal hepatic P450 activity).
Shipping conditions: Embryo/Spermatoza- Dry Ice
References:

Henderson et al. 2003. J Biol Chem. 278(15):13480-6. PMID: 12566435.

Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.

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