#151829

HRN Nude Mouse

Cat. #151829

HRN Nude Mouse

Cat. #: 151829

Sub-type: Mouse

Availability: 6-8 weeks

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Roland Wolf ; Colin Henderson

Institute: University of Dundee

Tool Details
Handling
Target Details
References

Tool Details

*FOR RESEARCH USE ONLY

  • Tool name: HRN Nude Mouse
  • Research fields: Cancer;Drug development;Genetics;Metabolism
  • Tool sub type: Mouse
  • Conditional: Yes
  • Description: A P450 Oxidoreductase hepatic null in nude background (ICRF nude mouse). This mouse has a conditional deletion of POR and may be used in the drug development process to establish role of P450 activity in anti-cancer drug efficacy in vivo.
  • Genetic background: The hepatic reductase null (HRN) line, which is PORlox/lox::CreALB, was crossed to the ICRF nude mouse. The ultimate experimental mouse is thus PORlox/lox::CreALB::nu/nu, with PORlox/lox::nu/nu as matched controls (the latter are essentially 'ordinary' nude mice, with normal POR expression, and thus normal hepatic P450 activity).
  • Production details: The hepatic reductase null (HRN) line, which is PORlox/lox::CreALB, was crossed to the ICRF nude mouse. The ultimate experimental mouse is thus PORlox/lox::CreALB::nu/nu, with PORlox/lox::nu/nu as matched controls (the latter are essentially 'ordinary' nude mice, with normal POR expression, and thus normal hepatic P450 activity).

Handling

  • Shipping conditions: Embryo/Spermatoza- Dry Ice

Target Details

  • Target: P450 Oxidoreductase

References

  • Henderson et al. 2003. J Biol Chem. 278(15):13480-6. PMID: 12566435.
  • Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase.