Cat. #160867
G0S2-flox mouse
Cat. #: 160867
Sub-type: Mouse
Availability: 8-10 weeks
Model: Knock-Out
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Franz Radner
Institute: University of Graz
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Tool name: G0S2-flox mouse
- Alternate name: G0/G1 swithc gene 2
- Research fields: Apoptosis and autophagy;Cancer;Cell biology;Metabolism
- Tool sub type: Mouse
- Model: Knock-Out
- Conditional: Yes
- Conditional description: Flox flanked gene ready for deletion
- Description: seful model for the generation of tissue/cell specific G0S2-deficient mice. Animals might be useful for studies, e.g.on energy metabolism or oncology.
- Genetic background: These mice were generated using HM1-ES cells. ES cell clones were injected into C57BL/6J blastocysts to enable coat colour selection of the chimeras. Mice were subsequently backcrossed to C57BL/6J (âĽÂ 10 generations). When kept as a homozygous colony, mice are backcrossed regularly to C57BL/6J to avoid generation of subpopulations.
- Phenotype: These mice are conditional ready, and phenotypical identical to C57BL/6J mice.
- Zygosity: Homozygous
- Strain: C57BL/6J
- Production details: The whole G0s2 gene sequence was targeted and flanked by loxP sites. Further details are available upon request.
- Breeding information: Good breeder. Homozygous mice may be bred together to maintain a live colony.
Target Details
- Target: G0/G1 switch gene 2
References
- Heier et al. 2015. J Biol Chem. 290(43):26141-50. PMID: 26350455.
