Cat. #154269
AEG-1DeltaMAC mouse
Cat. #: 154269
Sub-type: Mouse
Availability: 8-10 weeks
Disease: Hepatocellular Carcinogenesis
Model: Conditional KO
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Devanand Sarkar
Institute: Virginia Commonwealth University
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Tool name: AEG-1DeltaMAC mouse
- Research fields: Cancer;Cell signaling and signal transduction;Genetics;Immunology
- Tool sub type: Mouse
- Disease: Hepatocellular Carcinogenesis
- Model: Conditional KO
- Conditional: Yes
- Conditional description: Conditional AEG-1ÎMAC knockout after single i.p. injection of 10Âľg/gm body weight of N-nitrosodiethylamine (DEN) given at 14 days of age followed by 0.05% phenobarbital daily in drinking water.
- Description: Mouse model with conditional AEG-1 knockout in myeloid cells
- Genetic background: Floxed AEG-1 mice (AEG-1fl/fl) in C57BL/6 background were crossed with LysM/Cre (B6.129P2-Lyz2tm1(cre)lfo/J
- Phenotype: Hepatocellular Carcinogenesis
- Zygosity: unknown
- Strain: C57BL/6
- Production details: Floxed AEG-1 mice (AEG-1fl/fl) in C57BL/6 background were crossed with LysM/Cre (B6.129P2-Lyz2tm1(cre)lfo/J
Handling
- Shipping conditions: Embryo/Spermatoza- Dry Ice
Target Details
- Target: Astrocyte Elevated Gene-1
References
- Robertson et al. 2018. Cancer Res. 78(22):6436-6446. PMID: 30181179.
- Astrocyte Elevated Gene-1 Regulates Macrophage Activation in Hepatocellular Carcinogenesis.
