Cat. #153292
Sdhb -/- CL 5 Cell Line
Cat. #: 153292
Unit size: 1x10^6 cells / vial
Availability: 8-10 weeks
Organism: Mouse
Tissue: Kidney
Disease: Cancer
Model: Knock-Out
£575.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Eyal Gottlieb
Institute: Cancer Research UK, Glasgow: The Beatson Institute
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Sdhb -/- CL 5 Cell Line
- Alternate name: Succinate dehydrogenase, SDH, Succinate-coenzyme Q reductase, SQR
- Research fields: Cancer;Drug development;Metabolism
- Organism: Mouse
- Tissue: Kidney
- Disease: Cancer
- Model: Knock-Out
- Description: Succinate dehydrogenase (SDH) is an enzyme complex found in the inner mitochondrial membrane of mammalian mitochondria and many bacterial cells. SDH is the only enzyme that participates in both the electron transport chain and citric acid cycle. The enzymatic function of SDH oxidises succinate to fumarate in the tricarboxylic acid cycle and losing this function is associated with cancer formation.
- Biosafety level: 1
- Cellosaurus id: CVCL_HG12
Target Details
- Target: Succinate dehydrogenase
Handling
- Format: Frozen
- Unit size: 1x10^6 cells / vial
- Shipping conditions: Dry ice
- Storage conditions: Liquid Nitrogen
- Mycoplasma free: Yes
Related Tools
- Related tools: SDHB Floxed Mouse ; Sdhb -/- CL 7 Cell Line ; Sdhb fl/fl Cell Line
References
- Cardaci et al. 2015. Nat Cell Biol. 17(10):1317-26. PMID: 26302408.
- Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis.
