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#156416

Mutant DISC1 cell line

Cat. #156416

Mutant DISC1 cell line

Cat. #: 156416

Unit size: 1x10^6 cells / vial

Availability: 10-12 weeks

Disease: Schizophrenia

£575.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Mikhail Plentnikov

Institute: Johns Hopkins University

Tool Details
Target Details
Handling

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

  • Name: Mutant DISC1 cell line
  • Research fields: Drug development;Neurobiology
  • Parental cell: PC12
  • Disease: Schizophrenia
  • Description: To evaluate the effects of a predicted protein, mutant disrupted-in-schizophrenia 1 (DISC1), stable PC12 cell clones with inducible expression of mutant or full-length human DISC1 (hDISC1) have been generated. PC12 is a neuronal cell line derived from a pheochromocytoma of the rat brain. This technology includes an inducible Tet-off PC12 cell model with stable expression of full-length and truncated hDISC1, allowing for a regulated expression of hDISC1 in homogenous populations of cells. Inducible expression of DISC1 in PC12 cells is a valuable in vitro model for further studying the molecular mechanisms likely due to loss of function of DISC1 relevant to the pathogenesis of major mental illnesses.

Target Details

  • Target: disrupted-in-schizophrenia 1 (DISC1)

Handling

  • Format: Frozen
  • Unit size: 1x10^6 cells / vial
  • Shipping conditions: Dry ice

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