Cat. #151449
JIM1 Cell Line
Cat. #: 151449
Sub-type: Primary
Unit size: 1x10^6 cells / vial
Organism: Human
Tissue: Blood
Disease: Cancer
Model: Tumour line
£575.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: M.S. Hamilton
Institute: University of Birmingham
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: JIM1 Cell Line
- Alternate name: JIM-1; jim1
- Cancer: Blood cancer
- Cancers detailed: Human multiple myeloma
- Research fields: Cancer;Drug development;Genetics
- Tool sub type: Primary
- Organism: Human
- Gender: Female
- Tissue: Blood
- Disease: Cancer
- Growth properties: Suspension
- Model: Tumour line
- Conditional: Yes
- Description: JIM1 is a multiple myeloma cell line established from plasma myeloma cells derived from pleural fluid of an advanced multiple myeloma patient (Hamilton et al., 1991). The cell line exhibits deficient DNA mismatch repair (MMR) capacity with reduced heteroduplex G/T repair activity (Velangi et al., 2004). JIM1 displays a plasma cell phenotype (CD38+, PCA-1+, CD24+) (Hamilton et al., 1991) and serves as a well characterised model for studying DNA repair deficiency, and therapeutic vulnerabilities in multiple myeloma research.
- Production details: Derived from plasma myeloma cells from pleural fluid of advanced multiple myeloma female patient.
- Cellosaurus id: CVCL_2532
Handling
- Format: Frozen
- Growth medium: Dexter culture medium, consisting of Fischer's medium + 20% FCS +10-7 M hydrocortisone sodium succinate. Seed at 2-9 x 10 5 cells/cm3 5% CO2; 37 °C
- Unit size: 1x10^6 cells / vial
- Shipping conditions: Dry ice
References
- Brito et al. 2009. Haematologica. 94(1):78-86. PMID: 19059936.
- Leone et al. 2008. Clin Cancer Res. 14(19):6033-6041. PMID: 18829482.
- Velangi et al. 2004. Carcinogenesis. 25(10):1795-1803. PMID: 15142887.
- Hamilton et al. 1991. Leukemia. 5(9):768-771. PMID: 1943229.
