Cyclins bind to and regulate the activity of the Cyclin Dependent Protein Kinases (CDKs). Cyclin B1 is a marker of cell proliferation and a key component of the cell cycle progression machinery. Cyclin B1 may prove to be a prognostic marker in neoplasia.
| Inventor | Institute |
|---|---|
| Julian Gannon | Cancer Research UK, London Research Institute: Clare Hall Laboratories |
| Cat. #: | 151021 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology;Genetics |
| Application: | FACS ; IHC ; WB |
| Target: | Cyclin B1 |
| Reactivity: | Mammalian |
| Clone: | V152 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | CCNB1; Cyclin B1; G2/Mitotic-Specific Cyclin B1; CCNB |
|---|---|
| Product description: | Cyclins bind to and regulate the activity of the Cyclin Dependent Protein Kinases (CDKs). Cyclin B1 is a marker of cell proliferation and a key component of the cell cycle progression machinery. Cyclin B1 may prove to be a prognostic marker in neoplasia. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | His tagged Hamster Cyclin B1 expressed in bacteria, harvested from inclusion bodies, extracted with 6M guanidine HC1 and purified on Nickel beads. |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | Cyclins bind to and regulate the activity of the Cyclin Dependent Protein Kinases (CDKs). Cyclin B1 is a marker of cell proliferation and a key component of the cell cycle progression machinery. Cyclin B1 may prove to be a prognostic marker in neoplasia. |
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| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | '-15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Gurden et al. 2010. J Cell Sci. 123(Pt 3):321-30. PMID: 20053638. Cdc20 is required for the post-anaphase, KEN-dependent degradation of centromere protein F. Geley et al. 2001. J Cell Biol. 153(1):137-48. PMID: 11285280. Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint. Characterization of adriamycin-induced G2 arrest and its abrogation by caffeine in FL-amnion cells with or without p53. Minemoto et al. 2001. Exp Cell Res. 262(1):37-48. PMID: 11120603. Brandeis et al. 1998. Proc Natl Acad Sci U S A. 95(8):4344-9. PMID: 9539739. Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero. |
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