Monoclonal antibody directed at against Lewis X antigen, with use in differentiating between leukaemia’s and aids in the purification of stem cells.
| Inventor | Institute |
|---|---|
| Nancy Hogg | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151042 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Immunology |
| Application: | FACS |
| Target: | Lewis X (CD15) |
| Reactivity: | Human |
| Clone: | 29 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | Fucosyltransferase 4; Galactoside 3-L-Fucosyltransferase; ELAM-1 Ligand Fucosyltransferase; FUC-TIV; FCT3A; ELFT; Stage-Specific Embryonic Antigen; Alpha (1,3) Fucosyltransferase; EC 2.4.1.65; Lewis X; SSEA-1; FUTIV; CD15; LeX |
|---|---|
| Product description: | Monoclonal antibody directed at against Lewis X antigen, with use in differentiating between leukaemia's and aids in the purification of stem cells. |
| Conjugation: | Unconjugated |
| Isotype: | IgM |
| Molecular weight: | 83 kDa |
| Immunogen: | Fibronectin purified human monocytes . |
| Immunogen Uniprot ID: | P22083 |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | Lewis X (CD15) is a branched pentasaccharide found on glycolipids, glycoproteins and proteoglycans of cells of gastric mucosa, nervous system, neutrophils, eosinophils, and monocytes. Lewis X is distributed abnormally in myeloid leukaemia's and is commonly used in the diagnosis of Hodgkin's disease. Lewis X is believed to enhance cell adhesion, either directly or by promoting integrin activation. Cells with high surface expression of Lewis X antigen, display strong self-aggregation, based on calcium-dependent Lewis X-Lewis X interaction. Anti-Lewis X (29) is useful for leukaemia typing and the purification of stem cells. |
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| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | Store at -20° C frozen. Avoid repeated freeze / thaw cycles |
| Shipping conditions: | Dry ice |
| References: |
Bernstein I & Self S. Report of the myeloid section of the Second International Workshop on Leucocyte Typing II, Human leucocyte Differentiation Antigens. Published by Springer-Verlag, New York. 1986. |
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