In humans, 4A1, 4A2, & 4A3 have been cloned from liver, kidney and testis and have been detected in renal, hepatic & brain microvessels.
| Inventor | Institute |
|---|---|
| Roland Wolf | University of Dundee |
| Cat. #: | 151038 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell signaling and signal transduction;Metabolism;Tissue-specific biology |
| Application: | ELISA ; IP ; WB |
| Target: | Cytochrome P450 4A2, 4A3, CYP4A2, CYP4A3 |
| Reactivity: | Rat |
| Clone: | Clo4 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | Cyclin-Dependent Kinase 1; Cell Division Cycle 2, G1 To S And G2 To M; Cell Division Control Protein 2 Homolog; Cell Division Protein Kinase 1; P34 Protein Kinase; P34CDC2; CDC28A; CDC2; Cell Cycle Controller CDC2; CDKN1 |
|---|---|
| Product description: | The CYP2 family are part of the microsomal drug metabolising system that is responsible for the oxidation of many therapeutic agents as well as steroids, fatty acids and many other endogenous substances. The hepatic CYP4A enzymes are important fatty acid and prostaglandin omega-hydroxylases that are highly inducible by fibric acid hypolipidemic agents and other peroxisome proliferators. In humans, 4A1, 4A2, & 4A3 have been cloned from liver, kidney and testis and have been detected in renal, hepatic & brain microvessels. |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Molecular weight: | 51.5/52.0 kDa |
| Immunogen: | Rat liver cytochrome P450 4A2 and 4A3 |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | The CYP2 family are part of the microsomal drug metabolising system that is responsible for the oxidation of many therapeutic agents as well as steroids, fatty acids and many other endogenous substances. The hepatic CYP4A enzymes are important fatty acid and prostaglandin omega-hydroxylases that are highly inducible by fibric acid hypolipidemic agents and other peroxisome proliferators. In humans, 4A1, 4A2, & 4A3 have been cloned from liver, kidney and testis and have been detected in renal, hepatic & brain microvessels. |
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| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Lukaszewicz et al. 2013. Clin Sci (Lond). 124(5):333-42. PMID: 22938512. Introgression of Brown Norway CYP4A genes on to the Dahl salt-sensitive background restores vascular function in SS-5(BN) consomic rats. |
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