DM1-1 iPAX7-hiPS cell line

Myotonic dystrophy is a genetic disease characterized by a loss of muscle function. Myotonic dystrophy type 1 (DM1), the most common form of myotonia, is caused by mutations in the DMPK gene. Currently, there is no cure or treatment for DM1. DM1-1 iPAX7-hiPS cell line is part of a panel of 4 cell lines: 2 […]

Contributors

Inventor Institute
Rita Perlingeiro Kyba The University of Minnesota Twin Cities
Cat. #: 157740
Unit size: 1×10^6 cells / vial
Research Fields: Cell signaling and signal transduction;Drug development
Organism: Human
Model: Stem Cells
Primary citation: Mondragon-Gonzalez and Perlingeiro. 2018. Dis Model Mech. 18:11(7)dmm034728. PMID: 29898953
Alternate name: Myotonic dystrophy 1 (DM-1)
Product description: Myotonic dystrophy is a genetic disease characterized by a loss of muscle function. Myotonic dystrophy type 1 (DM1), the most common form of myotonia, is caused by mutations in the DMPK gene. Currently, there is no cure or treatment for DM1. 4 total cell lines are available: 2 undifferentiated hiPSC lines from two DM1 patients (DM1-1 hiPS cell line, DM1-2 hiPS cell line) and 2 differentiated skeletal muscle cell lines (DM1-1 iPAX7-hiPS cell line and DM1-2 iPAX7-hiPS cell line).
Production details: To generate a cell-based model for DM1, researchers obtained a sample of skin fibroblasts from two diagnosed DM1 patients. These fibroblasts (DM1-1 and DM1-2) were reprogrammed to hiPS cells via the Sendai virus method. Following reprogramming, DM1-1 and DM1-2 hiPS cells were modified to express PAX7 under the presence of exogenous doxycycline. Expression of PAX7 results in the differentiation of the DM1-1 and DM1-2 hiPSC cells into skeletal muscle cells. These differentiated muscle cells re…
Parental cell line: Skin fibroblasts from a diagnosed 35-year-old male DM1 patient
Disease: Muscular dystrophy
Format: Frozen
Shipping conditions: Dry ice
References:

Mondragon-Gonzalez and Perlingeiro. 2018. Dis Model Mech. 18:11(7)dmm034728. PMID: 29898953

Related Tools for Cell lines

Cat. # Tool Name
151445 1-7HB2 Cell Line Key Info View Tool
151446 FLYRD18 Cell Line Key Info View Tool
151447 CMT 64 Cell Line Key Info View Tool
151665 MEF PKCe KO Cell Line Key Info View Tool
151576 MEF RAF1 KO Cell Line Key Info View Tool

Related News

UM-UC-10 Cell Line. Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC), UK.
Cell Lines

Popular cell lines now available only from CancerTools.org

Read More
Cell Lines

New cell lines: murine melanocyte and melanoblast cell lines from Dr. Elena Sviderskaya

Read More
Image Reference: 2x PTEN -/- mouse prostate cancer cell lines (MuCap system). Histology staining of syngraft tumours (Van Duijn et al., 2018).
Cell Lines

38 new prostate cancer cell lines

Read More

Tool enquiry

Please ensure you use your organisation email address rather than personal where possible, as this helps us locate your organisation in our system faster.

Please note we may take up to three days to respond to your enquiry.

CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.