Nucleotide excision repair (NER) is a DNA repair pathway that removes lesions induced by a variety of agents such as UV irradiation. ERCC1 and XPF form the heterodimer ERCC1-XPF, forming a DNA endonuclease that is essential for the dual incision step of NER (cleaves 5′ of the DNA lesion).
| Inventor | Institute |
|---|---|
| Rick Wood | Cancer Research UK, London Research Institute: Clare Hall Laboratories |
| Cat. #: | 153204 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Genetics |
| Application: | IF ; WB |
| Target: | XPF |
| Reactivity: | Human |
| Clone: | 4H4 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | DNA excision repair protein ERCC-4, DNA repair protein complementing XP-F cells, Xeroderma pigmentosum group F-complementing protein |
|---|---|
| Product description: | Nucleotide excision repair (NER) is a DNA repair pathway that removes lesions induced by a variety of agents such as UV irradiation. ERCC1 and XPF form the heterodimer ERCC1-XPF, forming a DNA endonuclease that is essential for the dual incision step of NER (cleaves 5' of the DNA lesion). |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | Nucleotide excision repair (NER) is a DNA repair pathway that removes lesions induced by a variety of agents such as UV irradiation. ERCC1 and XPF form the heterodimer ERCC1-XPF, forming a DNA endonuclease that is essential for the dual incision step of NER (cleaves 5' of the DNA lesion). |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Bhagwat et al. 2009. Cancer Res. 69(17):6831-8. PMID: 19723666. Immunodetection of DNA repair endonuclease ERCC1-XPF in human tissue. |
|---|
| Cat. # | Tool Name | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 151030 | Anti-Progesterone [11P14] |
Key Info
Anti-Progesterone [11P14]
|
View Tool | |||||||||||||||||||
| 151024 | Anti-Hairy [1/24] |
Key Info
Anti-Hairy [1/24]
|
View Tool | |||||||||||||||||||
| 151028 | Anti-Cytochrome P450 2C2, 2B1/2 [h7] |
Key Info
Anti-Cytochrome P450 2C2, 2B1/2 [h7]
|
View Tool | |||||||||||||||||||
| 151031 | Anti-RuvA [RuvA 12C6] |
Key Info
Anti-RuvA [RuvA 12C6]
|
View Tool | |||||||||||||||||||
| 151035 | Anti-CD8 [14] mAb |
Key Info
Anti-CD8 [14] mAb
|
View Tool | |||||||||||||||||||
Please note we may take up to three days to respond to your enquiry.
CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.