Anti-Transmembrane protein [3B5/D7]

Although K15 does not exhibit homology to LMP2A, both proteins contain a similar structural organisation, and modulate lymphocyte signalling. K15 targets the major B cell Src kinase-Lyn and this interaction appears to be important in transcriptional modulation of NFAT/AP1 activities.

Contributors

Inventor Institute
Tyson Sharp University College London (UCL)
Cat. #: 151610
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Apoptosis and autophagy;Biochemistry;Microbiology
Application: ELISA ; IF ; IP ; WB
Target: K15 (putative integral transmembrane protein similar to LMP2A)
Reactivity: Human ; Virus
Clone: 3B5/D7
Host: Mouse
Class: Monoclonal
Product description: Kaposi's sarcoma-associated herpesvirus (KSHV) is a member of the human herpesviruses and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD). KSHV encodes a distinct open reading frame called K15 at a position equivalent to the gene encoding LMP2A of Epstein-Barr virus (EBV). Although K15 does not exhibit homology to LMP2A, both proteins contain a similar structural organisation, and modulate lymphocyte signalling. K15 targets the major B cell Src kinase-Lyn and this interaction appears to be important in transcriptional modulation of NFAT/AP1 activities.
Conjugation: Unconjugated
Isotype: IgG1
Molecular weight: 50 kDa (full) to 17 kDa
Immunogen: Recombinant protein
Myeloma used: P3X63Ag8.653
Target background: Kaposi's sarcoma-associated herpesvirus (KSHV) is a member of the human herpesviruses and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD). KSHV encodes a distinct open reading frame called K15 at a position equivalent to the gene encoding LMP2A of Epstein-Barr virus (EBV). Although K15 does not exhibit homology to LMP2A, both proteins contain a similar structural organisation, and modulate lymphocyte signalling. K15 targets the major B cell Src kinase-Lyn and this interaction appears to be important in transcriptional modulation of NFAT/AP1 activities.
Format: Liquid
Storage conditions: -80° C
Shipping conditions: Dry ice
References:

Sharp et al. 2002. J Virol. 76(2):802-16. PMID: 11752170.

K15 protein of Kaposi's sarcoma-associated herpesvirus is latently expressed and binds to HAX-1, a protein with antiapoptotic function.

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