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#151610

Anti-Transmembrane protein [3B5/D7]

Cat. #151610

Anti-Transmembrane protein [3B5/D7]

Cat. #: 151610

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 10-12 weeks

Target: K15 (putative integral transmembrane protein similar to LMP2A)

Class: Monoclonal

Application: ELISA ; IF ; IP ; WB

Reactivity: Human ; Virus

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Tyson Sharp

Institute: University College London (UCL)

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

  • Name: Anti-Transmembrane protein [3B5/D7]
  • Research fields: Apoptosis and autophagy;Biochemistry;Microbiology
  • Clone: 3B5/D7
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Molecular weight: 50 kDa (full) to 17 kDa
  • Strain: Balb/c
  • Reactivity: Human ; Virus
  • Host: Mouse
  • Application: ELISA ; IF ; IP ; WB
  • Description: Kaposi's sarcoma-associated herpesvirus (KSHV) is a member of the human herpesviruses and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD). KSHV encodes a distinct open reading frame called K15 at a position equivalent to the gene encoding LMP2A of Epstein-Barr virus (EBV). Although K15 does not exhibit homology to LMP2A, both proteins contain a similar structural organisation, and modulate lymphocyte signalling. K15 targets the major B cell Src kinase-Lyn and this interaction appears to be important in transcriptional modulation of NFAT/AP1 activities.
  • Immunogen: Recombinant protein
  • Isotype: IgG1
  • Myeloma used: P3X63Ag8.653

Target Details

  • Target: K15 (putative integral transmembrane protein similar to LMP2A)
  • Molecular weight: 50 kDa (full) to 17 kDa
  • Target background: Kaposi's sarcoma-associated herpesvirus (KSHV) is a member of the human herpesviruses and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD). KSHV encodes a distinct open reading frame called K15 at a position equivalent to the gene encoding LMP2A of Epstein-Barr virus (EBV). Although K15 does not exhibit homology to LMP2A, both proteins contain a similar structural organisation, and modulate lymphocyte signalling. K15 targets the major B cell Src kinase-Lyn and this interaction appears to be important in transcriptional modulation of NFAT/AP1 activities.

Applications

  • Application: ELISA ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Unit size: 100 ug
  • Storage conditions: -80° C
  • Shipping conditions: Dry ice

References

  • Sharp et al. 2002. J Virol. 76(2):802-16. PMID: 11752170.
  • K15 protein of Kaposi's sarcoma-associated herpesvirus is latently expressed and binds to HAX-1, a protein with antiapoptotic function.

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