Spectrin is a cytoskeletal protein that lines the intracellular side of the plasma membrane of many cell types in pentagonal or hexagonal arrangements, forming a scaffolding and playing an important role in maintenance of plasma membrane integrity and cytoskeletal structure. In certain types of brain injury such as diffuse axonal injury, spectrin is irreversibly cleaved […]
| Inventor | Institute |
|---|---|
| Jacqueline Cordell | University of Oxford |
| Cat. #: | 151403 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Biochemistry;Neurobiology;Tissue-specific biology |
| Application: | WB ; IHC ; IF ; IP ; WB |
| Target: | Spectrin |
| Reactivity: | Human |
| Clone: | RG/26 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Spectrin is a cytoskeletal protein that lines the intracellular side of the plasma membrane of many cell types in pentagonal or hexagonal arrangements, forming a scaffolding and playing an important role in maintenance of plasma membrane integrity and cytoskeletal structure. In certain types of brain injury such as diffuse axonal injury, spectrin is irreversibly cleaved by the proteolytic enzyme calpain, destroying the cytosketelon. Spectrin cleavage causes the membrane to form blebs and ulti… |
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| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Immunogen: | Red cell membranes |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | Spectrin is a cytoskeletal protein that lines the intracellular side of the plasma membrane of many cell types in pentagonal or hexagonal arrangements, forming a scaffolding and playing an important role in maintenance of plasma membrane integrity and cytoskeletal structure. In certain types of brain injury such as diffuse axonal injury, spectrin is irreversibly cleaved by the proteolytic enzyme calpain, destroying the cytosketelon. Spectrin cleavage causes the membrane to form blebs and ulti… |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Wagner et al. 2014. Vox Sang. 106(1):45-54. PMID: 23909508. Impact of constant storage temperatures and multiple warming cycles on the quality of stored red blood cells. Sachanonta et al. 2008. Asian Pac J Allergy Immunol. 26(1):37-45. PMID: 18595528. Host vascular endothelial growth factor is trophic for Plasmodium falciparum-infected red blood cells. |
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