Cat. #151403
Anti-Spectrin [RG/26] mAb
Cat. #: 151403
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 1-2 weeks
Target: Spectrin
Class: Monoclonal
Application: WB ; IHC ; IF ; IP ; WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Jacqueline Cordell
Institute: University of Oxford
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-Spectrin [RG/26] mAb
- Research fields: Biochemistry;Neurobiology;Tissue-specific biology
- Clone: RG/26
- Tool sub type: Primary antibody
- Class: Monoclonal
- Purpose: Marker
- Conjugation: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: WB ; IHC ; IF ; IP ; WB
- Description: Spectrin is a cytoskeletal protein that lines the intracellular side of the plasma membrane of many cell types in pentagonal or hexagonal arrangements, forming a scaffolding and playing an important role in maintenance of plasma membrane integrity and cytoskeletal structure. In certain types of brain injury such as diffuse axonal injury, spectrin is irreversibly cleaved by the proteolytic enzyme calpain, destroying the cytosketelon. Spectrin cleavage causes the membrane to form blebs and ulti...
- Immunogen: Red cell membranes
- Isotype: IgG2a
- Myeloma used: P3/NS1/1-Ag4.1
Target Details
- Target: Spectrin
- Tissue cell line specificity: Mouse
- Target background: Spectrin is a cytoskeletal protein that lines the intracellular side of the plasma membrane of many cell types in pentagonal or hexagonal arrangements, forming a scaffolding and playing an important role in maintenance of plasma membrane integrity and cytoskeletal structure. In certain types of brain injury such as diffuse axonal injury, spectrin is irreversibly cleaved by the proteolytic enzyme calpain, destroying the cytosketelon. Spectrin cleavage causes the membrane to form blebs and ulti...
Applications
- Application: WB ; IHC ; IF ; IP ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
References
- Wagner et al. 2014. Vox Sang. 106(1):45-54. PMID: 23909508.
- Impact of constant storage temperatures and multiple warming cycles on the quality of stored red blood cells.
- Sachanonta et al. 2008. Asian Pac J Allergy Immunol. 26(1):37-45. PMID: 18595528.
- Host vascular endothelial growth factor is trophic for Plasmodium falciparum-infected red blood cells.
