The protein is also expressed on and a useful marker for peripheral monocytes. It is also useful for distinguishing myelogenous leukaemia cells from lymphoid or erythroid leukaemias.
| Inventor | Institute |
|---|---|
| Paul Crocker | University of Oxford |
| Cat. #: | 151728 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology;Immunology;Stem cell biology |
| Application: | ELISA ; WB |
| Target: | CD33 |
| Reactivity: | Human |
| Clone: | CD33 1C7/1 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | Sialic Acid Binding Ig Like Lectin 12; SIGLECL1; SLG 3; Siglec-12; Siglec-L1; S2V |
|---|---|
| Product description: | CD33 is found on granulocyte and macrophage precursors in the bone marrow, but is not on pluripotent stem cells. The protein is also expressed on and a useful marker for peripheral monocytes. It is also useful for distinguishing myelogenous leukaemia cells from lymphoid or erythroid leukaemias. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | Extracellular portion of CD33 fused to the Fc portion of human IgG1 |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | CD33 is found on granulocyte and macrophage precursors in the bone marrow, but is not on pluripotent stem cells. The protein is also expressed on and a useful marker for peripheral monocytes. It is also useful for distinguishing myelogenous leukaemia cells from lymphoid or erythroid leukaemias. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -80° C |
| Shipping conditions: | Dry ice |
| References: |
Taylor et al. 1999. J Biol Chem. 274(17):11505-12. PMID: 10206955. The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2. Freeman et al. 1995. Blood. 85(8):2005-12. PMID: 7718872. Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules. |
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