Monoclonal antibody used to aid understanding the method of SARS membrane fusion and entry.
| Institute |
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| A*STAR Accelerate Technologies Pte Ltd |
| Cat. #: | 152651 |
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| Unit size: | 100 ug |
| Research Fields: | Microbiology |
| Application: | IP ; WB |
| Target: | S protein of the SARS coronavirus |
| Reactivity: | Virus |
| Clone: | 7G12 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Monoclonal antibody used to aid understanding the method of SARS membrane fusion and entry. Severe acute respiratory syndrome coronavirus (SARS-CoV) is a species of coronavirus known to infect humans, bats, and certain other mammals. The SARS-related coronavirus is an enveloped, positive-sense, single-stranded RNA virus which enters its host cell by the ACE2 receptor. SARS genome encodes for four structural proteins, namely nucleocaspid (N), spike (S), membrane (M) and envelope (E). The S protein, which forms morphologically characteristic projections on the virion surface, is responsible for binding to cellular receptor and mediating the fusion between viral and cellular membranes. The S?3 is a fragment containing residues from 168 to 461 of the S protein. This antibody has use in investigating the mechanism of membrane fusion and virus entry. |
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| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | GST-S?3 fusion protein |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | Monoclonal antibody used to aid understanding the method of SARS membrane fusion and entry. Background and Research Application Severe acute respiratory syndrome coronavirus (SARS-CoV) is a species of coronavirus known to infect humans, bats, and certain other mammals. The SARS-related coronavirus is an enveloped, positive-sense, single-stranded RNA virus which enters its host cell by the ACE2 receptor. SARS genome encodes for four structural proteins, namely nucleocaspid (N), spike (S), membrane (M) and envelope (E). The S protein, which forms morphologically characteristic projections on the virion surface, is responsible for binding to cellular receptor and mediating the fusion between viral and cellular membranes. The SÄÂĂÂ3 is a fragment containing residues from 168 to 461 of the S protein. This antibody has use in investigating the mechanism of membrane fusion and virus entry. |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Lip et al. 2006. J Virol. 80(2):941-50. PMID: 16378996. Lip et al. 2006. J Virol. 80(2):941-50. PMID: 16378996. Monoclonal antibodies targeting the HR2 domain and the region immediately upstream of the HR2 of the S protein neutralize in vitro infection of severe acute respiratory syndrome coronavirus. |
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