RAD51C is a Rad51 paralog. RAD51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. RAD51C is also a component for the […]
| Inventor | Institute |
|---|---|
| Stephen West | Cancer Research UK, London Research Institute: Clare Hall Laboratories |
| Cat. #: | 151286 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Genetics |
| Application: | IF ; IHC ; IP ; WB |
| Target: | Rad51C |
| Clone: | Rad51C 2H11/6 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | RAD51C is a Rad51 paralog. RAD51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. RAD51C is also a component for the homologous recombination pathway. |
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| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | Rad51C 2H11/6 was raised against His-tagged human Rad51C, overexpressed in e.coli and purified on a talon affinity column under denaturing conditions, followed by gel purification on a SDS-Page |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | RAD51C is a Rad51 paralog. RAD51 is a eukaryotic homologue of E. coli RecA, a recombinase, and a component of the homologous recombination DNA repair pathway. RAD51 forms a nucleoprotein filament (through binding RAD52 and single stranded DNA that are exposed following double strand breaks) that initiates recombination. RAD51C is also a component for the homologous recombination pathway. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Park et al. 2014. Oncogene. 33(40):4803-12. PMID: 24141787. Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair. French et al. 2002. J Biol Chem. 277(22):19322-30. PMID: 11912211. Role of mammalian RAD51L2 (RAD51C) in recombination and genetic stability. Masson et al. 2001. Genes Dev. 15(24):3296-307. PMID: 11751635. Identification and purification of two distinct complexes containing the five RAD51 paralogs. Masson et al. 2001. Proc Natl Acad Sci U S A. 98(15):8440-6. PMID: 11459987. Complex formation by the human RAD51C and XRCC3 recombination repair proteins. Dosanjh et al. 1998. Nucleic Acids Res. 26(5):1179-84. PMID: 9469824. Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes. |
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