Monoclonal antibody specific to human PTPN2 in both its 45 kDa and 48 kDa variants.
| Inventor | Institute |
|---|---|
| Tony Tiganis | Monash University |
| Cat. #: | 161585 |
|---|---|
| Tool sub type: | Primary antibody |
| Cancer types: | Blood cancer;Breast cancer |
| Research Fields: | Cancer;Cell signaling and signal transduction;Immunology;Neurobiology |
| Application: | WB, IHC |
| Target: | PTPN2 |
| Reactivity: | Human |
| Clone: | RE5a |
| Host: | Mouse |
| Class: | Monoclonal |
| Primary citation: | Goh PK et al. 2022. Sci Adv. 8(8):eabk3338. PMID: 35196085. |
| Alternate name: | Protein Tyrosine Phosphatase Non-Receptor Type 2 Monoclonal Antibody |
|---|---|
| Product description: | This monoclonal antibody recognizes human PTPN2 at an epitope between AA 1-317, which includes the PTPN2 catalytic domain. This region is identical between the 45 kDa and 48 kDa variants, and RE5a can detect PTPN2 at both its nuclear and cytoplasmic locations. |
| Isotype: | IgG3 kappa |
| Molecular weight: | 45 kDa |
| Immunogen: | recombinant human 45-kDa PTPN2 |
| Target background: | PTPN2 encodes a protein tyrosine phosphatase which has influence on T cell recruitment and function. The 48 kDa variant and is found on the cytosoic side of the ER, and the 45 kDa variant is targeted to the nucleus and cytoplasm. Targets of PTPN2 include Src family kinases, JAK kinases, and (only for the 45 kDa protein) various STAT proteins. PTPN2 is a tumor suppressor gene afflilated with triple negative breast cancer. PTPN2 also plays a role in anti-tumor immunity and T cell activation. |
|---|
| Storage conditions: | -20° C |
|---|---|
| Shipping conditions: | Dry ice |
| References: |
Goh PK et al. 2022. Sci Adv. 8(8):eabk3338. PMID:ĂÂ 35196085. |
|---|
| Cat. # | Tool Name | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 151019 | Anti-Mos [S3.1] |
Key Info
Anti-Mos [S3.1]
|
View Tool | |||||||||||||||||||
| 151022 | Anti-IL12 [1-1A4] |
Key Info
Anti-IL12 [1-1A4]
|
View Tool | |||||||||||||||||||
| 151034 | Anti-HSVUL42 [13D11] |
Key Info
Anti-HSVUL42 [13D11]
|
View Tool | |||||||||||||||||||
| 151037 | Anti-Cdk1 [17 (A17)] |
Key Info
Anti-Cdk1 [17 (A17)]
|
View Tool | |||||||||||||||||||
| 151038 | Anti-Cytochrome P450 4A2, 4A3 [Clo4] |
Key Info
Anti-Cytochrome P450 4A2, 4A3 [Clo4]
|
View Tool | |||||||||||||||||||
Please note we may take up to three days to respond to your enquiry.
CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.