PD-ECGF expression is elevated in breast tumours and is a prognostic factor in colon tumours.
| Inventor | Institute |
|---|---|
| Roy Bicknell | University of Oxford |
| Cat. #: | 151220 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Immunology;Tissue-specific biology |
| Application: | IHC ; IF ; IP ; WB |
| Target: | Platelet-derived endothelial cell growth factor (thymidine phosphorylase); PD-ECGF. |
| Reactivity: | Human |
| Clone: | PGF 44C |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | PD-ECGF expression is elevated in breast tumours and is a prognostic factor in colon tumours. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 55 kDa (reduced) |
| Immunogen: | Full length human protein in E. coli |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | PD-ECGF expression is elevated in breast tumours and is a prognostic factor in colon tumours. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Weng et al. 2012. Basic Clin Pharmacol Toxicol. 110(3):298-306. PMID: 21973306. Enhancement of mitomycin C-induced cytotoxicity by curcumin results from down-regulation of MKK1/2-ERK1/2-mediated thymidine phosphorylase expression. Ko et al. 2011. J Pharmacol Exp Ther. 338(1):184-94. PMID: 21444628. Up-regulation of extracellular signal-regulated kinase 1/2-dependent thymidylate synthase and thymidine phosphorylase contributes to cisplatin resistance in human non-small-cell lung cancer cells. Giatromanolaki et al. 2003. J Pathol. 200(2):222-8. PMID: 12754744. DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer. Fox et al. 1997. Ann Oncol. 8(3):271-5. PMID: 9137797. Relationship of elevated tumour thymidine phosphorylase in node-positive breast carcinomas to the effects of adjuvant CMF. Fox et al. 1995. J Pathol. 176(2):183-90. PMID: 7636628. Platelet-derived endothelial cell growth factor/thymidine phosphorylase expression in normal tissues: an immunohistochemical study. Moghaddam et al. 1995. Proc Natl Acad Sci U S A. 92(4):998-1002. PMID: 7532308. Thymidine phosphorylase is angiogenic and promotes tumor growth. |
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