Anti-p53 [Pab 1802]

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-p53 [Pab 1802]
• Alternate name: Tumor Protein P53; Phosphoprotein P53; Antigen NY-CO-13; P53; Transformation-Related Protein 53; Mutant Tumor Protein 53; Li-Fraumeni Syndrome; P53 Tumor Suppressor; Tumor Suppressor P53; TRP53; BCC7; LFS1
• Cancer: Other
• Cancers detailed: Broadly Applicable
• Research fields: Apoptosis and autophagy;Cancer;Cell biology;Genetics
• Clone: Pab 1802
• Tool sub type: Primary antibody
• Class: Monoclonal
• Conjugation: Unconjugated
• Molecular weight: 53 kDa
• Strain: Balb/c
• Reactivity: Human ; Mouse
• Host: Mouse
• Application: ELISA ; IHC ; IP ; WB
• Description: Pab 1802 is a monoclonal antibody for p53. Pab 1802 recognises an epitope on the C-terminus of p53 in both the wild-type and mutant p53. Pab 1802 has been used to show the expression of human p53 cDNA in cos-I cells.
• Immunogen: P53-beta galactosidase fusion protein
• Isotype: IgG1
• Myeloma used: P3/NS1/1-Ag4.1
• Recommended controls: MDA-MB-231 cell line

Target Details

• Target: p53
• Molecular weight: 53 kDa
• Tissue cell line specificity: MDA-MB-231 cell line
• Target background: p53 is a crucial tumour suppressor involved in over 50% of cancers. It acts as a stress-responsive transcription factor and plays a vital role in regulating cell cycle arrest, promoting apoptosis, maintaining genomic stability, controlling the cell cycle, and inhibiting angiogenesis. Known as the "guardian of the genome," p53 prevents gene mutations. Mutations in the p53 gene are common in human cancers, resulting in dysfunctional proteins unable to bind to DNA. This loss of fun...

Applications

• Application: ELISA ; IHC ; IP ; WB

Handling

• Format: Liquid
• Concentration: 1 mg/ml
• Unit size: 100 ug
• Storage buffer: PBS with 0.02% azide
• Storage conditions: -15° C to -25° C
• Shipping conditions: Dry ice

References

• Banks et al. 1986. Eur J Biochem. 159(3):529-34. PMID: 2428616.