Pab 1802 is a monoclonal antibody for p53. Pab 1802 recognises an epitope on the C-terminus of p53 in both the wild-type and mutant p53. Pab 1802 has been used to show the expression of human p53 cDNA in cos-I cells.
| Inventor | Institute |
|---|---|
| Lawrence Banks | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151145 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Cancer types: | Other |
| Research Fields: | Apoptosis and autophagy;Cancer;Cell biology;Genetics |
| Application: | ELISA ; IHC ; IP ; WB |
| Target: | p53 |
| Reactivity: | Human ; Mouse |
| Clone: | Pab 1802 |
| Host: | Mouse |
| Class: | Monoclonal |
| Primary citation: | Banks et al. 1986. Eur J Biochem. 159(3):529-34. PMID: 2428616. |
| Alternate name: | Tumor Protein P53; Phosphoprotein P53; Antigen NY-CO-13; P53; Transformation-Related Protein 53; Mutant Tumor Protein 53; Li-Fraumeni Syndrome; P53 Tumor Suppressor; Tumor Suppressor P53; TRP53; BCC7; LFS1 |
|---|---|
| Product description: | Pab 1802 is a monoclonal antibody for p53. Pab 1802 recognises an epitope on the C-terminus of p53 in both the wild-type and mutant p53. Pab 1802 has been used to show the expression of human p53 cDNA in cos-I cells. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 53 kDa |
| Immunogen: | P53-beta galactosidase fusion protein |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | p53 is a crucial tumour suppressor involved in over 50% of cancers. It acts as a stress-responsive transcription factor and plays a vital role in regulating cell cycle arrest, promoting apoptosis, maintaining genomic stability, controlling the cell cycle, and inhibiting angiogenesis. Known as the "guardian of the genome," p53 prevents gene mutations. Mutations in the p53 gene are common in human cancers, resulting in dysfunctional proteins unable to bind to DNA. This loss of fun… |
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| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Banks et al. 1986. Eur J Biochem. 159(3):529-34. PMID: 2428616. |
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