Anti-ORC1 [ORC1 7F6/1]

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.

Contributors

Institute
Cancer Research UK, London Research Institute: Clare Hall Laboratories
Cat. #: 151191
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Genetics
Application: IP ; ChIP ; ELISA ; IHC ; IP ; WB ; ChIP-seq
Target: ORC1
Reactivity: Human
Clone: ORC1 7F6/1
Host: Mouse
Class: Monoclonal
Product description: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Conjugation: Unconjugated
Isotype: IgG1
Molecular weight: 45-97 kDa
Immunogen: Bacterially expressed Human ORC1
Myeloma used: Sp2/0-Ag14
Target background: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Format: Liquid
Concentration: 0.76 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Lu et al. 2016. Biol Open. 5(10):1449-1460. PMID: 27744293.

Beck et al. 2012. Genes Dev. 26(23):2580-9. PMID: 23152447.

Salsi et al. 2009. Mol Cell Biol. 29(21):5775-88. PMID: 19703996.

Burke et al. 2001. J Biol Chem. 276(18):15397-408. PMID: 11278932.

Images

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Adapted from Lu et al. Biology Open (2016) 5; 1449-1460 doi

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