Cat. #160584
Anti-mEMILIN1 [mEMIL]
Cat. #: 160584
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 10-12 weeks
Target: mEMILIN1
Class: Monoclonal
Application: ELISA ; IHC ; IF ; WB
Reactivity: Mouse
Host: Rat
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Alfonso Colombatti ; Roberto Doliana ; Paola Spessotto ; Maria Teresa Mucignat
Institute: National Cancer Institute CRO - Aviano
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-mEMILIN1 [mEMIL]
- Research fields: Cancer;Cell biology
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Reactivity: Mouse
- Host: Rat
- Application: ELISA ; IHC ; IF ; WB
- Description: Emilin-1 (Elastin Microfibril Interface Located proteIN) is an extracellular matrix glycoprotein. Is part of a protein family which have been shown to be expressed in smooth muscle and other mesenchymal tissues and is localized at the proximity of elastin and microfibrils. Emilin-1 interacts with the ÄÂ?4ÄÂ?1 integrin via the C-terminal gC1q domain. It binds pro-TGFB preventing its maturation to mature TGFB in the extracellular space, therefore influencing the regulation of blood and lymph vessels formation and maintenance.
- Immunogen: Recombinant murine Emilin-1 as immunizing antigen; Wistar rat as host
- Recommended controls: IgG2a kappa
Target Details
- Target: mEMILIN1
- Tissue cell line specificity: IgG2a kappa
- Target background: Emilin-1 (Elastin Microfibril Interface Located proteIN) is an extracellular matrix glycoprotein. Is part of a protein family which have been shown to be expressed in smooth muscle and other mesenchymal tissues and is localized at the proximity of elastin and microfibrils. Emilin-1 interacts with the a4?1 integrin via the C-terminal gC1q domain. It binds pro-TGFB preventing its maturation to mature TGFB in the extracellular space, therefore influencing the regulation of blood and lymph vessel...
Applications
- Application: ELISA ; IHC ; IF ; WB
Handling
- Format: Liquid
- Unit size: 100 ug
- Storage conditions: Store at 2 - 8° C or aliquots at -20° C. Avoid repeated freeze-thaw cycles
- Shipping conditions: Shipping at 4° C
Related Tools
- Related tools: Anti-hEMILIN2 [hEMIL2] monoclonal antibody ; Anti-mMMRN2 [mMMRN2] monoclonal antibody ; Anti-mMMRN2 [mMMRN2] monoclonal antibody ; Anti-hEMILIN1 [hEMIL1] monoclonal antibody
References
- Pivetta et al. 2016. Clin Sci (Lond). 130(14):1221-36. PMID: 26920215.
- Capuano et al. 2016. Hum Mutat. 37(1):84-97. PMID: 26462740.
- Danussi et al. 2013. Mol Cell Biol. 33(22):4381-94. PMID: 24019067.
- Danussi et al. 2012. Cancer Prev Res (Phila). 5(9):1131-43. PMID: 22827975.
- Danussi et al. 2011. J Cell Biol. 195(1):131-45. PMID: 21949412.
- Danussi et al. 2008. Mol Cell Biol. 28(12):4026-39. PMID: 18411305.
- Zacchigna et al. 2006. Cell. 124(5):929-42. PMID: 16530041.
