Anti-Laminin alpha 5 monoclonal antibody 8G9
| Inventor | Institute |
|---|---|
| Sulev Ingerpuu | University of Tartu |
| Cat. #: | 162127 |
|---|---|
| Application: | ELISA ; IHC |
| Target: | Laminin alpha 5 |
| Reactivity: | Human |
| Clone: | 8G9 |
| Host: | Mouse |
| Class: | Monoclonal |
| Primary citation: | Wondimu et al. 2004. Blood 104(6): 1859-1865. PMID: 15172971 |
| Product description: | Anti-Laminin alpha 5 (LMa5) monoclonal antibody recognises an epitope near the integrin-binding domain of the LMa5 chain. This antibody clone was shown to inhibit Α3 Β1/Α6 Β1 integrin-mediated adhesion and migration of glioma, melanoma, and carcinoma cells on laminin-511 (Wondimu et al. 2013). This antibody has a novel epitope localised at or near the integrin-binding globular domain of the LMΑ5 chain, which is essential for cell adhesion and migration, and identifies a potential therapeutic target in malignant and inflammatory diseases. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 400 kDa |
| Immunogen: | Natural human laminin-511 purified from A549 lung adenocarcinoma cells |
| Target background: | Laminin alpha 5 is one of the subunits of laminin 5, one of the extracellular matrix glycoproteins abundantly present in the basement membranes of blood vessels. Laminin 5 is involved in many biological processes, such as cell adhesion, differentiation, migration, signalling, neurite outgrowth and metastasis. |
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| Shipping conditions: | Dry ice |
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| References: |
Wondimu et al. (2013). PLoS ONE 8(1): e53648. PMID: 23308268 Wondimu et al. 2004. Blood 104(6): 1859-1865. PMID: 15172971 |
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