#162127

Anti-Laminin alpha 5 [8G9]

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Cat. #162127

Anti-Laminin alpha 5 [8G9]

Cat. #: 162127

Target: Laminin alpha 5

Class: Monoclonal

Application: ELISA ; IHC

Reactivity: Human

Host: Mouse

£300.00

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Contributor

Inventor: Sulev Ingerpuu

Institute: University of Tartu

Primary Citation: Wondimu et al. 2004. Blood 104(6): 1859-1865. PMID: 15172971

Tool Details
Target Details
Applications
Related Tools
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Anti-Laminin alpha 5 [8G9]
  • Clone: 8G9
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Cell signalling pathway: ERK
  • Molecular weight: 400 kDa
  • Reactivity: Human
  • Host: Mouse
  • Disease: Nephrotic Syndrome, Type 26 and Bent Bone Dysplasia Syndrome 2
  • Application: ELISA ; IHC
  • Description: Anti-Laminin alpha 5 (LMa5) monoclonal antibody recognises an epitope near the integrin-binding domain of the LMa5 chain. This antibody clone was shown to inhibit Α3 Β1/Α6 Β1 integrin-mediated adhesion and migration of glioma, melanoma, and carcinoma cells on laminin-511 (Wondimu et al. 2013). This antibody has a novel epitope localised at or near the integrin-binding globular domain of the LMΑ5 chain, which is essential for cell adhesion and migration, and identifies a potential therapeutic target in malignant and inflammatory diseases.
  • Immunogen: Natural human laminin-511 purified from A549 lung adenocarcinoma cells
  • Isotype: IgG1

Target Details

  • Target: Laminin alpha 5
  • Target alternate names: LAMA5, Laminin, alpha 5, laminin subunit alpha 5
  • Molecular weight: 400 kDa
  • Target background: Laminin alpha 5 is one of the subunits of laminin 5, one of the extracellular matrix glycoproteins abundantly present in the basement membranes of blood vessels. Laminin 5 is involved in many biological processes, such as cell adhesion, differentiation, migration, signalling, neurite outgrowth and metastasis.

Applications

  • Application: ELISA ; IHC
  • Application notes: For ELISA, a working concentration of 1 mg/ml is recommended

Related Tools

  • Related tools: Monoclonal antibody 4B12 anti laminin alpha 5

References

  • Wondimu et al. (2013). PLoS ONE 8(1): e53648. PMID: 23308268
  • Wondimu et al. 2004. Blood 104(6): 1859-1865. PMID: 15172971