Anti-CyclinA [E72.1]

Tool Details

*FOR RESEARCH USE ONLY

• Name: Anti-CyclinA [E72.1]
• Alternate name: CCNA1; Cyclin A1; Testicular Tissue Protein Li 34; CT146
• Clone: E72.1
• Tool type ecom: Antibodies
• Tool sub type: Primary antibody
• Class: Monoclonal
• Conjugation: Unconjugated
• Reactivity: Bovine
• Host: Mouse
• Application: IHC ; IF ; IP ; WB
• Description: Cyclins bind to and regulate the activity of the Cyclin Dependent Protein Kinases (CDKs). Cyclin A is involved in the regulation of the cell cycle and is essential for progression through S phase. Cyclin A protein is absent in cells prior to S-phase, during which its levels increase and peak. Cyclin A is a marker for actively proliferating cells and for cells in S phase.
• Immunogen: Bovine Cyclin A
• Isotype: IgG1
• Myeloma used: Sp2/0-Ag14

Target Details

• Target: Cyclin A
• Target background: Cyclins bind to and regulate the activity of the Cyclin Dependent Protein Kinases (CDKs). Cyclin A is involved in the regulation of the cell cycle and is essential for progression through S phase. Cyclin A protein is absent in cells prior to S-phase, during which its levels increase and peak. Cyclin A is a marker for actively proliferating cells and for cells in S phase.

Applications

• Application: IHC ; IF ; IP ; WB

Handling

• Format: Liquid
• Concentration: 0.9-1.1 mg/ml
• Unit size: 100 ug
• Storage buffer: PBS with 0.02% azide
• Storage conditions: -15° C to -25° C
• Shipping conditions: Shipping at 4° C

References

• Garner et al. 2002. Oncogene. 21(53):8089-104. PMID: 12444545.
• Delta MEKK3:ER* activation induces a p38 alpha/beta 2-dependent cell cycle arrest at the G2 checkpoint.
• Bashir et al. 2000. Proc Natl Acad Sci U S A. 97(10):5522-7. PMID: 10792046.
• Cyclin A activates the DNA polymerase delta -dependent elongation machinery in vitro: A parvovirus DNA replication model.