Cyclins bind to and regulate the activity of the Cyclin Dependent Protein Kinases (CDKs). Cyclin A is involved in the regulation of the cell cycle and is essential for progression through S phase.
| Inventor | Institute |
|---|---|
| Julian Gannon | Cancer Research UK, London Research Institute: Clare Hall Laboratories |
| Cat. #: | 151016 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology;Genetics |
| Application: | IHC ; IF ; IP ; WB |
| Target: | Cyclin A |
| Reactivity: | Bovine |
| Clone: | E72.1 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | CCNA1; Cyclin A1; Testicular Tissue Protein Li 34; CT146 |
|---|---|
| Product description: | Cyclins bind to and regulate the activity of the Cyclin Dependent Protein Kinases (CDKs). Cyclin A is involved in the regulation of the cell cycle and is essential for progression through S phase. Cyclin A protein is absent in cells prior to S-phase, during which its levels increase and peak. Cyclin A is a marker for actively proliferating cells and for cells in S phase. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | Bovine Cyclin A |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | Cyclins bind to and regulate the activity of the Cyclin Dependent Protein Kinases (CDKs). Cyclin A is involved in the regulation of the cell cycle and is essential for progression through S phase. Cyclin A protein is absent in cells prior to S-phase, during which its levels increase and peak. Cyclin A is a marker for actively proliferating cells and for cells in S phase. |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | '-15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Garner et al. 2002. Oncogene. 21(53):8089-104. PMID: 12444545. Delta MEKK3:ER* activation induces a p38 alpha/beta 2-dependent cell cycle arrest at the G2 checkpoint. Bashir et al. 2000. Proc Natl Acad Sci U S A. 97(10):5522-7. PMID: 10792046. Cyclin A activates the DNA polymerase delta -dependent elongation machinery in vitro: A parvovirus DNA replication model. |
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