Used in diagnosis of primitive neuroectodermal tumours. Binds to tumours of neural and glial origin and does not bind to paediatric or adult brain. Used for bone marrow purging and intrathecal targeting
| Inventor | Institute |
|---|---|
| John Kemshead | Institute of Child Health |
| Cat. #: | 151179 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology;Cell signaling and signal transduction;Neurobiology |
| Application: | IHC ; IP ; WB |
| Target: | L1 cell adhesion molecule (L1CAM; CD171) |
| Reactivity: | Human |
| Clone: | UJ181.4 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Used in diagnosis of primitive neuroectodermal tumours. Binds to tumours of neural and glial origin and does not bind to paediatric or adult brain. Used for bone marrow purging and intrathecal targeting |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 220-240 kDa |
| Immunogen: | 16 week human foetal brain. |
| Myeloma used: | P3X63Ag8.653 |
| Target background: | Used in diagnosis of primitive neuroectodermal tumours. Binds to tumours of neural and glial origin and does not bind to paediatric or adult brain. Used for bone marrow purging and intrathecal targeting |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Garson.JA. 1983. MD Thesis. Birmingham Bourne et al. 1989. Hybridoma. 8(4):415-26. PMID: 2550359. Monoclonal antibodies M340 and UJ181.4 recognize antigens associated with primitive neuroectodermal tumours/tissues. Coakham et al. 1985. J Clin Pathol. 38(2):165-73. PMID: 3881481. Immunohistological diagnosis of central nervous system tumours using a monoclonal antibody panel. Kemshead et al. 1983. Int J Cancer. 31(2):187-95. PMID: 6826247. Monoclonal antibody UJ 127:11 detects a 220,000-240,000 kdal. glycoprotein present on a sub-set of neuroectodermally derived cells. |
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