Anti-Integrin Beta 3 (GPIIIa, CD61) [AP-2]

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-Integrin Beta 3 (GPIIIa, CD61) [AP-2]
• Alternate name: CD-61
• Research fields: Immunology
• Class: Monoclonal
• Conjugation: Unconjugated
• Host: Mouse
• Application: ELISA ; FACS
• Description: Glycoprotein IIb/IIIa, also known as integrin aIIb?Ÿ3 is an integrin complex found on platelets. The complex acts as a receptor for both fibrogen and von Willebrand factor and helps in platelet activation. Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia, which is an abnormality in the platelets, or bleeding disorder.
• Immunogen: Human platelet
• Isotype: IgG1

Target Details

• Target: Integrin Beta 3 (GPIIIa, CD61) 
• Target background: Glycoprotein IIb/IIIa, also known as integrin aIIb?Ÿ3 is an integrin complex found on platelets. The complex acts as a receptor for both fibrogen and von Willebrand factor and helps in platelet activation. Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia, which is an abnormality in the platelets, or bleeding disorder.

Applications

• Application: ELISA ; FACS

Handling

• Format: Liquid
• Concentration: 0.9-1.1mg/ml
• Unit size: 100 ug
• Storage buffer: PBS with 0.02% azide
• Storage conditions: -15° C to -25° C
• Shipping conditions: Dry ice

References

• Pidard et al. 1983. J Biol Chem. 258(20):12582-6. PMID: 6226659.
• Interaction of AP-2, a monoclonal antibody specific for the human platelet glycoprotein IIb-IIIa complex, with intact platelets.