The F11 epitope is different to the MHF4 epitope.
| Inventor | Institute |
|---|---|
| Mike Horton | Queen Mary University of London |
| Cat. #: | 151093 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology;Tissue-specific biology;Cell signaling and signal transduction |
| Application: | FACS ; IHC ; IP ; Fn |
| Target: | Integrin ?3 (CD61) |
| Reactivity: | Human ; Rat |
| Clone: | F11 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | Neural Cell Adhesion Molecule; NCAM; CD56 Antigen; MSK39 |
|---|---|
| Product description: | The F11 epitope is different to the MHF4 epitope. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 180 kDa, 140 kDa, 120 kDa |
| Immunogen: | A bone cell suspension containing osteoclasts, osteoblasts and bone marrow cells obtained from the long bones of newborn Sprague Dawley rats. |
| Myeloma used: | P3X63Ag8.653 |
| Target background: | Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin b3 is expressed in osteoclasts, megacaryocytes and platelets. |
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| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
de Nigris et al. 2007. Oncogene. 26(3):382-94. PMID: 16878156. Cooperation between Myc and YY1 provides novel silencing transcriptional targets of alpha3beta1-integrin in tumour cells. Thompson et al. 2000. J Immunol. 165(1):426-34. PMID: 10861081. Divergent effects of platelet-endothelial cell adhesion molecule-1 and beta 3 integrin blockade on leukocyte transmigration in vivo. Shankar et al. 1993. J Cell Sci. 105 ( Pt 1):61-8. PMID: 7689577. Integrin receptor-mediated mobilisation of intranuclear calcium in rat osteoclasts. Helfrich et al. 1992. J Bone Miner Res. 7(3):345-51. PMID: 1585837. Helfrich et al. 1992. J Bone Miner Res. 7(3):335-43. PMID: 1585836. Integrins on rat osteoclasts: characterization of two monoclonal antibodies (F4 and F11) to rat beta 3. Rat osteoclasts adhere to a wide range of RGD (Arg-Gly-Asp) peptide-containing proteins, including the bone sialoproteins and fibronectin, via a beta 3 integrin. |
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