#151138

Anti-Integrin alpha 2b + beta 3 [P256]

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Cat. #151138

Anti-Integrin alpha 2b + beta 3 [P256]

Cat. #: 151138

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 1-2 weeks

Target: Integrin a2b?3 (CD41 & CD61)

Class: Monoclonal

Application: IHC ; IF ; IP ; WB

Reactivity: Human

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Nancy Hogg

Institute: Imperial College

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Anti-Integrin alpha 2b + beta 3 [P256]
  • Alternate name: alpha 2B/beta3, alphaIIbetabeta3, GPIIbetabeta3, CD41/CD61, platelet fibronectin receptor
  • Research fields: Cell signaling and signal transduction;Cell biology
  • Clone: P256
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Molecular weight: 135 kDa
  • Strain: Balb/c
  • Reactivity: Human
  • Host: Mouse
  • Application: IHC ; IF ; IP ; WB
  • Description: P256 induces aggregation of normal platelets in plasma.
  • Immunogen: Peripheral blood mononuclear cells
  • Isotype: IgG1
  • Myeloma used: P3/NS1/1-Ag4.1

Target Details

  • Target: Integrin a2b?3 (CD41 & CD61)
  • Molecular weight: 135 kDa
  • Target background: Integrins are heterodimeric cell surface receptors composed of a and ? subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin a2b (CD41) and integrin ?3 (CD61) associate to form the heterodimer integrin a2bb3 (CD41/CD61; GPIIb/IIIa), a fibronectin receptor expressed...

Applications

  • Application: IHC ; IF ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Shipping at 4° C

References

  • Activation of platelets induced by mAb P256 specific for glycoprotein IIb-IIIa. Possible evidence for a role for IIb-IIIa in membrane signal transduction.
  • 1989. Ann. Meeting Br. Nuclear Med. Soc. Abstracts. 243.
  • In vivo studies with an anti-platelet monoclonal antibody
  • P256.
  • Monoclonal antibodies specific for platelet glycoproteins react with human monocytes.