Anti-integrin a3 inhibiting

Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. Integrin ?3 (P1B5) is a mouse monoclonal antibody developed to identify four distinct classes (I, II, III, IV) of cell surface receptors for native collagen. P1B5 inhibited attachment to type VI and I collagens and partially inhibited […]

Contributors

Inventor Institute
Elizabeth A. Wayner, William Carter Fred Hutchinson Cancer Center
Cat. #: 161656
Tool sub type: Primary antibody
Research Fields: Cell biology
Application: FACS, Function Blocking, Immunofluorescence, Immunohistochemistry, Immunoprecipitation
Target: Integrin alpha-3 (CD49b)
Reactivity: Human
Clone: P1B5
Host: Mouse
Class: Monoclonal
Primary citation: Wayner et al.1987. Journal of Cell Biology.105(4):1873-84. PMID: 2822727
Product description: Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. Integrin ?3 (P1B5) is a mouse monoclonal antibody developed to identify four distinct classes (I, II, III, IV) of cell surface receptors for native collagen. P1B5 inhibited attachment to type VI and I collagens and partially inhibited attachment to fibronectin and laminin as well.
Isotype: IgG1
Molecular weight: 119kDa
Immunogen: HT1080 human fibrosarcoma cell line
Target background: ?2?1 complex of Collagen receptors: I, II, III, IV. P1B5 inhibits cell adhesion to collagen and fibronectin.
Storage conditions: For immediate use, short term storage at 4°C up to two weeks is recommended. For long term storage, divide the solution into volumes of no less than 20 ul for freezing at -20°C or -80°C. The small volume aliquot should provide sufficient reagent for short term use. Freeze-thaw cycles should be avoided. For concentrate or bioreactor products, an equal volume of glycerol, a cryoprotectant, may be added prior to freezing.
Shipping conditions: Dry ice
References:

Wayner et al.1987. Journal of Cell Biology.105(4):1873-84.PMID: 2822727

Carter et al.1990. J Cell Biol.111(6 ):3141-54.PMID: 2269668

Symington et al. 1993.J Cell Biol.120(2):523-35.PMID: 8421064

Related Tools for Antibodies

Cat. # Tool Name
151017 Anti-MBP [R29.6] Key Info View Tool
151021 Anti-CyclinB1 [V152] Key Info View Tool
151023 Anti-IL12 [1-1D5] Key Info View Tool
151031 Anti-RuvA [RuvA 12C6] Key Info View Tool
151040 Anti-CD11 & CD18 [24] Key Info View Tool

Tool enquiry

Please ensure you use your organisation email address rather than personal where possible, as this helps us locate your organisation in our system faster.

Please note we may take up to three days to respond to your enquiry.

CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.