Anti-integrin a3 inhibiting

Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. Integrin ?3 (P1B5) is a mouse monoclonal antibody developed to identify four distinct classes (I, II, III, IV) of cell surface receptors for native collagen. P1B5 inhibited attachment to type VI and I collagens and partially inhibited […]

Contributors

Inventor Institute
Elizabeth A. Wayner, William Carter Fred Hutchinson Cancer Center
Cat. #: 161656
Tool sub type: Primary antibody
Research Fields: Cell biology
Application: FACS, Function Blocking, Immunofluorescence, Immunohistochemistry, Immunoprecipitation
Target: Integrin alpha-3 (CD49b)
Reactivity: Human
Clone: P1B5
Host: Mouse
Class: Monoclonal
Primary citation: Wayner et al.1987. Journal of Cell Biology.105(4):1873-84. PMID: 2822727
Product description: Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. Integrin ?3 (P1B5) is a mouse monoclonal antibody developed to identify four distinct classes (I, II, III, IV) of cell surface receptors for native collagen. P1B5 inhibited attachment to type VI and I collagens and partially inhibited attachment to fibronectin and laminin as well.
Isotype: IgG1
Molecular weight: 119kDa
Immunogen: HT1080 human fibrosarcoma cell line
Target background: ?2?1 complex of Collagen receptors: I, II, III, IV. P1B5 inhibits cell adhesion to collagen and fibronectin.
Storage conditions: For immediate use, short term storage at 4°C up to two weeks is recommended. For long term storage, divide the solution into volumes of no less than 20 ul for freezing at -20°C or -80°C. The small volume aliquot should provide sufficient reagent for short term use. Freeze-thaw cycles should be avoided. For concentrate or bioreactor products, an equal volume of glycerol, a cryoprotectant, may be added prior to freezing.
Shipping conditions: Dry ice
References:

Wayner et al.1987. Journal of Cell Biology.105(4):1873-84.PMID: 2822727

Carter et al.1990. J Cell Biol.111(6 ):3141-54.PMID: 2269668

Symington et al. 1993.J Cell Biol.120(2):523-35.PMID: 8421064

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