#152765

Anti-HPV18E6 [C1N1]

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Cat. #152765

Anti-HPV18E6 [C1N1]

Cat. #: 152765

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 1-2 weeks

Target: Human papillomavirus type 18 (HPV-18) specific epitopes on the E6 polypeptide

Class: Monoclonal

Application: ELISA ; IP ; WB

Reactivity: Virus

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Lawrence Banks

Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Anti-HPV18E6 [C1N1]
  • Alternate name: HPV-18 E6, HPV-18 E6 protein, HPV18 E6, HPV18E6
  • Cancer: Gynaecologic cancer
  • Cancers detailed: Cervical
  • Research fields: Cancer;Microbiology
  • Clone: C1N1
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Molecular weight: 16.5 kDa
  • Strain: Balb/c
  • Reactivity: Virus
  • Host: Mouse
  • Application: ELISA ; IP ; WB
  • Description: The human papilloma virus (HPV) family of DNA tumor viruses includes HPV-16 and HPV-18, which are associated with a large proportion of cervical cancer cases. HPV early proteins E6 and E7 are the major viral oncoproteins that regulate cell proliferation through the inactivation of p53 and Rb1 tumour suppressor proteins respectively. BF7 can be used for detection of HPV in cervical smears and biopsies and analysis of E6 expression in cell transformation studies.
  • Immunogen: HPV18E6-beta-galactosidase fusion protein synthesized in E. coli
  • Isotype: IgG
  • Myeloma used: P3/NS1/1-Ag4.1
  • Recommended controls: HPV infected tissue

Target Details

  • Target: Human papillomavirus type 18 (HPV-18) specific epitopes on the E6 polypeptide
  • Molecular weight: 16.5 kDa
  • Tissue cell line specificity: HPV infected tissue
  • Target background: The human papilloma virus (HPV) family of DNA tumor viruses includes HPV-16 and HPV-18, which are associated with a large proportion of cervical cancer cases. HPV early proteins E6 and E7 are the major viral oncoproteins that regulate cell proliferation through the inactivation of p53 and Rb1 tumour suppressor proteins respectively. BF7 can be used for detection of HPV in cervical smears and biopsies and analysis of E6 expression in cell transformation studies.

Applications

  • Application: ELISA ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Shipping at 4° C

References

  • Banks et al. 1987. J Gen Virol. 68 ( Pt 5):1351-9. PMID: 3033140.
  • Identification of human papillomavirus type 18 E6 polypeptide in cells derived from human cervical carcinomas.