BF7 can be used for detection of HPV in cervical smears and biopsies and analysis of E6 expression in cell transformation studies.
| Inventor | Institute |
|---|---|
| Lawrence Banks | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 152765 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Cancer types: | Gynaecologic cancer |
| Research Fields: | Cancer;Microbiology |
| Application: | ELISA ; IP ; WB |
| Target: | Human papillomavirus type 18 (HPV-18) specific epitopes on the E6 polypeptide |
| Reactivity: | Virus |
| Clone: | C1N1 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | HPV-18 E6, HPV-18 E6 protein, HPV18 E6, HPV18E6 |
|---|---|
| Product description: | The human papilloma virus (HPV) family of DNA tumor viruses includes HPV-16 and HPV-18, which are associated with a large proportion of cervical cancer cases. HPV early proteins E6 and E7 are the major viral oncoproteins that regulate cell proliferation through the inactivation of p53 and Rb1 tumour suppressor proteins respectively. BF7 can be used for detection of HPV in cervical smears and biopsies and analysis of E6 expression in cell transformation studies. |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Molecular weight: | 16.5 kDa |
| Immunogen: | HPV18E6-beta-galactosidase fusion protein synthesized in E. coli |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | The human papilloma virus (HPV) family of DNA tumor viruses includes HPV-16 and HPV-18, which are associated with a large proportion of cervical cancer cases. HPV early proteins E6 and E7 are the major viral oncoproteins that regulate cell proliferation through the inactivation of p53 and Rb1 tumour suppressor proteins respectively. BF7 can be used for detection of HPV in cervical smears and biopsies and analysis of E6 expression in cell transformation studies. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Banks et al. 1987. J Gen Virol. 68 ( Pt 5):1351-9. PMID: 3033140. Identification of human papillomavirus type 18 E6 polypeptide in cells derived from human cervical carcinomas. |
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