Human Leukocyte Antigens are highly polymorphic proteins that are involved in the presentation of antigens to the T-cell receptor. There are two classes of HLA antigens, class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). TAL 16.1 is useful for distinguishing DR1 homozygotes from DR1, DR103 heterozygotes.
| Inventor | Institute |
|---|---|
| Julia Bodmer | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 152692 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Immunology |
| Application: | ELISA ; FACS ; IHC ; WB |
| Target: | Human leukocyte antigens DR16, 103, 11, 12, 13, 8, 7, 4 (Dw10 only), DR51 |
| Reactivity: | Human |
| Clone: | TAL 16.1 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Human Leukocyte Antigens are highly polymorphic proteins that are involved in the presentation of antigens to the T-cell receptor. There are two classes of HLA antigens, class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). TAL 16.1 is useful for distinguishing DR1 homozygotes from DR1, DR103 heterozygotes. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Molecular weight: | 29 kDa |
| Immunogen: | Mouse L cell transfected with a Human HLA Class II (HLADRB5*0101) gene |
| Myeloma used: | NS0 |
| Target background: | Human Leukocyte Antigens are highly polymorphic proteins that are involved in the presentation of antigens to the T-cell receptor. There are two classes of HLA antigens, class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). TAL 16.1 is useful for distinguishing DR1 homozygotes from DR1, DR103 heterozygotes. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Sadler et al. 1993. Tissue Antigens. 41(1):42-6. PMID: 7681224. The monoclonal antibody TAL16.1 recognizes the aspartic acid residue at position 70 in DRB gene products. Altmann et al. 1990. Immunogenetics. 32(1):51-5. PMID: 1695613. Fine mapping of HLA class II monoclonal antibody specificities using transfected L cells. |
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