Anti-Fbxo7 [HLA3]

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-Fbxo7 [HLA3]
• Research fields: Cell biology;Genetics
• Clone: HLA3
• Tool sub type: Primary antibody
• Class: Polyclonal
• Conjugation: Unconjugated
• Molecular weight: ~59/~70 kDa
• Reactivity: Human ; Mouse
• Host: Rabbit
• Application: IHC ; IP ; WB
• Description: Recessive mutations in FBXO7/PARK15 cause an atypical EOPD. In certain cancers, the protein is highly expressed. These cell lines all express Fbxo7: U2OS, SHSY5Y, HEK293, Jurkat, SKOV3, HeLa, Ba-F3, Nalm6, C33A, MEL, HSPCs, MEFs.
• Immunogen: aa 499-522 of human Fbxo7 synthetic peptide coupled to KLH
• Recommended controls: Any cultured cell line grown in FBS

Target Details

• Target: Fbxo7
• Molecular weight: ~59/~70 kDa
• Tissue cell line specificity: Any cultured cell line grown in FBS
• Target background: Recessive mutations in FBXO7/PARK15 cause an atypical EOPD. In certain cancers, the protein is highly expressed. These cell lines all express Fbxo7: U2OS, SHSY5Y, HEK293, Jurkat, SKOV3, HeLa, Ba-F3, Nalm6, C33A, MEL, HSPCs, MEFs.

Applications

• Application: IHC ; IP ; WB

Handling

• Format: Liquid
• Unit size: 100 ug
• Shipping conditions: Dry ice

References

• Burchell et al. 2013. Nat Neurosci. 16(9):1257-65. PMID: 23933751.
• The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy.
• Meziane el et al. 2011. J Cell Sci. 124(Pt 13):2175-86. PMID: 21652635.
• Knockdown of Fbxo7 reveals its regulatory role in proliferation and differentiation of haematopoietic precursor cells.
• Laman et al. 2005. EMBO J. 24(17):3104-16. PMID: 16096642.
• Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6.