#151883

Anti-Fbxo7 [HLA3]

Cat. #151883

Anti-Fbxo7 [HLA3]

Cat. #: 151883

Sub-type: Primary antibody

Unit size: 100 ug

Target: Fbxo7

Class: Polyclonal

Application: IHC ; IP ; WB

Reactivity: Human ; Mouse

Host: Rabbit

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Heike Laman

Institute: University College London (UCL)

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

  • Name: Anti-Fbxo7 [HLA3]
  • Research fields: Cell biology;Genetics
  • Clone: HLA3
  • Tool sub type: Primary antibody
  • Class: Polyclonal
  • Conjugation: Unconjugated
  • Molecular weight: ~59/~70 kDa
  • Reactivity: Human ; Mouse
  • Host: Rabbit
  • Application: IHC ; IP ; WB
  • Description: Recessive mutations in FBXO7/PARK15 cause an atypical EOPD. In certain cancers, the protein is highly expressed. These cell lines all express Fbxo7: U2OS, SHSY5Y, HEK293, Jurkat, SKOV3, HeLa, Ba-F3, Nalm6, C33A, MEL, HSPCs, MEFs.
  • Immunogen: aa 499-522 of human Fbxo7 synthetic peptide coupled to KLH
  • Recommended controls: Any cultured cell line grown in FBS

Target Details

  • Target: Fbxo7
  • Molecular weight: ~59/~70 kDa
  • Tissue cell line specificity: Any cultured cell line grown in FBS
  • Target background: Recessive mutations in FBXO7/PARK15 cause an atypical EOPD. In certain cancers, the protein is highly expressed. These cell lines all express Fbxo7: U2OS, SHSY5Y, HEK293, Jurkat, SKOV3, HeLa, Ba-F3, Nalm6, C33A, MEL, HSPCs, MEFs.

Applications

  • Application: IHC ; IP ; WB

Handling

  • Format: Liquid
  • Unit size: 100 ug
  • Shipping conditions: Shipping at 4° C

References

  • Burchell et al. 2013. Nat Neurosci. 16(9):1257-65. PMID: 23933751.
  • The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy.
  • Meziane el et al. 2011. J Cell Sci. 124(Pt 13):2175-86. PMID: 21652635.
  • Knockdown of Fbxo7 reveals its regulatory role in proliferation and differentiation of haematopoietic precursor cells.
  • Laman et al. 2005. EMBO J. 24(17):3104-16. PMID: 16096642.
  • Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6.