Anti-FANCB [M38P3E10]

FANCB is a DNA repair protein required for FANCD2 ubiquitination. Defects in FANCB are the cause of Fanconi anemia complementation group B (FANCB), a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia.

Contributors

Inventor Institute
Ayham Alnabulsi Vertebrate Antibodies Limited
Cat. #: 152796
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer;Genetics
Application: ELISA ; IHC ; WB
Target: Fanconi Anemia, Complementation Group B (FANCB)
Reactivity: Human
Clone: M38P3E10
Host: Mouse
Class: Monoclonal
Alternate name: FA2, FAAP9, FAAP95, FAB, FACB, Fancb, FANCB_HUMAN, Fanconi anemia associated polypeptide of 95 kDa, Fanconi anemia group B protein, Fanconi anemia, complementation group B, Fanconi anemia-associated polypeptide of 95 kDa, Protein FACB
Product description: FANCB is a DNA repair protein required for FANCD2 ubiquitination. Defects in FANCB are the cause of Fanconi anemia complementation group B (FANCB), a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
Conjugation: Unconjugated
Isotype: IgG1 kappa
Molecular weight: 98 kDa
Immunogen: Ovalbumin-conjugated synthetic peptide- DRRENIHPYR
Myeloma used: P3X63Ag8.653
Target background: FANCB is a DNA repair protein required for FANCD2 ubiquitination. Defects in FANCB are the cause of Fanconi anemia complementation group B (FANCB), a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice

Images

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Immunohistochemistry was performed on formalin-fixed; paraffin-embedded human breast cancer tissue sections using Anti-FANCB [M38P3E10]. The antibody shows both nuclear and cytoplasmic staining but it is predominately cytoplasmic.

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