Cat. #151529
Anti-Factor VIII [RFF-VIII:c/8]
Cat. #: 151529
Unit size: 100 ug
Availability: 10-12 weeks
Target: Factor VIII
Class: Monoclonal
Application: IF ; Fn ; WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Alison Goodall
Institute: University College London (UCL)
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-Factor VIII [RFF-VIII:c/8]
- Research fields: Tissue-specific biology
- Clone: RFF-VIII:c/8
- Class: Monoclonal
- Conjugation: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: IF ; Fn ; WB
- Description: The commonest severe congenital bleeding disorder in all races is haemophilia A. The characteristic defect is a lack of coagulation factor VIII:C. Factor VIII:C is a glycoprotein that functions as a cofactor for factor IXa which, in the presence of calcium and phospholipids, converts factor X to the activated form Xa. This antibody binds to human FVIII:C heavy chain and inhibits its function.
- Immunogen: Purified human factor VIII
- Isotype: IgG1 kappa
- Myeloma used: P3/NS1/1-Ag4.1
Target Details
- Target: Factor VIII
- Target background: The commonest severe congenital bleeding disorder in all races is haemophilia A. The characteristic defect is a lack of coagulation factor VIII:C. Factor VIII:C is a glycoprotein that functions as a cofactor for factor IXa which, in the presence of calcium and phospholipids, converts factor X to the activated form Xa. This antibody binds to human FVIII:C heavy chain and inhibits its function.
Applications
- Application: IF ; Fn ; WB
Handling
- Format: Liquid
- Unit size: 100 ug
- Shipping conditions: Dry ice
Related Tools
- Related tools: Anti-Factor VIII:c heavy chain [RFF-VIII:c/10] ; Anti-Factor VIII:c light chain [RFF-VIII:c/5]
References
- Takase et al. 1987. Br J Haematol. 66(4):497-502. PMID: 3117089.
- Production of factor VIII deficient plasma by immunodepletion using three monoclonal antibodies.
- Goodall et al. 1985. Thromb Haemost. 54(4):878-91. PMID: 3937279.
- Registry of monoclonal antibodies to factor VIII and von Willebrand factor. International Committee on Thrombosis and Haemostasis.
- Rotblat et al. 1985. Biochemistry. 24(16):4294-300. PMID: 2413885.
- Purification of human factor VIII:C and its characterization by Western blotting using monoclonal antibodies.
- Vehar et al. 1984. Nature. 312(5992):337-42. PMID: 6438527.
- Structure of human factor VIII.
- Rotblat et al. 1983. J Lab Clin Med. 101(5):736-46. PMID: 6403638.
- Monoclonal antibodies to human procoagulant factor VIII.
