#151529

Anti-Factor VIII [RFF-VIII:c/8]

Cat. #151529

Anti-Factor VIII [RFF-VIII:c/8]

Cat. #: 151529

Unit size: 100 ug

Availability: 10-12 weeks

Target: Factor VIII

Class: Monoclonal

Application: IF ; Fn ; WB

Reactivity: Human

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Alison Goodall

Institute: University College London (UCL)

Tool Details
Target Details
Applications
Handling
Related Tools
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Anti-Factor VIII [RFF-VIII:c/8]
  • Clone: RFF-VIII:c/8
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Reactivity: Human
  • Host: Mouse
  • Application: IF ; Fn ; WB
  • Description: The commonest severe congenital bleeding disorder in all races is haemophilia A. The characteristic defect is a lack of coagulation factor VIII:C. Factor VIII:C is a glycoprotein that functions as a cofactor for factor IXa which, in the presence of calcium and phospholipids, converts factor X to the activated form Xa. This antibody binds to human FVIII:C heavy chain and inhibits its function.
  • Immunogen: Purified human factor VIII
  • Isotype: IgG1 kappa
  • Myeloma used: P3/NS1/1-Ag4.1

Target Details

  • Target: Factor VIII
  • Target background: The commonest severe congenital bleeding disorder in all races is haemophilia A. The characteristic defect is a lack of coagulation factor VIII:C. Factor VIII:C is a glycoprotein that functions as a cofactor for factor IXa which, in the presence of calcium and phospholipids, converts factor X to the activated form Xa. This antibody binds to human FVIII:C heavy chain and inhibits its function.

Applications

  • Application: IF ; Fn ; WB

Handling

  • Format: Liquid
  • Unit size: 100 ug
  • Shipping conditions: Shipping at 4° C

Related Tools

  • Related tools: Anti-Factor VIII:c heavy chain [RFF-VIII:c/10] ; Anti-Factor VIII:c light chain [RFF-VIII:c/5]

References

  • Takase et al. 1987. Br J Haematol. 66(4):497-502. PMID: 3117089.
  • Production of factor VIII deficient plasma by immunodepletion using three monoclonal antibodies.
  • Goodall et al. 1985. Thromb Haemost. 54(4):878-91. PMID: 3937279.
  • Registry of monoclonal antibodies to factor VIII and von Willebrand factor. International Committee on Thrombosis and Haemostasis.
  • Rotblat et al. 1985. Biochemistry. 24(16):4294-300. PMID: 2413885.
  • Purification of human factor VIII:C and its characterization by Western blotting using monoclonal antibodies.
  • Vehar et al. 1984. Nature. 312(5992):337-42. PMID: 6438527.
  • Structure of human factor VIII.
  • Rotblat et al. 1983. J Lab Clin Med. 101(5):736-46. PMID: 6403638.
  • Monoclonal antibodies to human procoagulant factor VIII.