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#152632

Anti-EBV Latent Membrane Protein 1 [LMPO24]

Cat. #152632

Anti-EBV Latent Membrane Protein 1 [LMPO24]

Cat. #: 152632

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 3-4 weeks

Target: Epstein-Barr Virus, Latent Membrane Protein 1 (EBV-LMP1)

Class: Monoclonal

Application: FACS ; IHC

Reactivity: Virus

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Martin Rowe

Institute: University of Birmingham

Tool Details
Target Details
Applications
Handling
Related Tools
References

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

  • Name: Anti-EBV Latent Membrane Protein 1 [LMPO24]
  • Research fields: Cancer;Cell biology;Cell signaling and signal transduction;Immunology;Microbiology
  • Clone: LMPO24
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Strain: Balb/c
  • Reactivity: Virus
  • Host: Mouse
  • Application: FACS ; IHC
  • Description: Monoclonal antibody which can be used to investigate EBV latency and EBV-associated malignant cells. Background and Research Application EBV is a human herpesvirus that establishes a life-long persistence in the host. The virus infects the vast majority of the world's adult population and is well known for its association with a broad spectrum of benign and malignant diseases. These include infectious mononucleosis, Burkitt's lymphoma, nasopharyngeal carcinoma, and is causally associated with lymphoid and epithelial malignancies, including post-transplant lymphoproliferative disorders, Hodgkin's disease, anaplastic nasopharyngeal carcinoma and gastric carcinomas. This antibody is specific for latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV). LMP1 is a transforming protein that affects multiple cell signalling pathways and contributes to EBV-associated oncogenesis. This protein can be expressed in some states of EBV latency, and significant induction of full-length LMP1 is also observed frequently during virus reactivation into the lytic cycle. LMP1 is critical for EBV-infected cell activation, adhesion and survival, and is usually expressed in the malignant cells.
  • Immunogen: Purified plasma membranes from LMP1 expressing insect cells infected with a recombinant LMP1 baculovirus
  • Immunogen uniprot id: P03230
  • Isotype: IgG1 kappa
  • Recommended controls: EBV transformed lymphoblastoid cell lines

Target Details

  • Target: Epstein-Barr Virus, Latent Membrane Protein 1 (EBV-LMP1)
  • Tissue cell line specificity: EBV transformed lymphoblastoid cell lines
  • Target background: Monoclonal antibody which can be used to investigate EBV latency and EBV-associated malignant cells. Background and Research Application EBV is a human herpesvirus that establishes a life-long persistence in the host. The virus infects the vast majority of the world's adult population and is well known for its association with a broad spectrum of benign and malignant diseases. These include infectious mononucleosis, Burkitt's lymphoma, nasopharyngeal carcinoma, and is causally associated with lymphoid and epithelial malignancies, including post-transplant lymphoproliferative disorders, Hodgkin's disease, anaplastic nasopharyngeal carcinoma and gastric carcinomas. This antibody is specific for latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV). LMP1 is a transforming protein that affects multiple cell signalling pathways and contributes to EBV-associated oncogenesis. This protein can be expressed in some states of EBV latency, and significant induction of full-length LMP1 is also observed frequently during virus reactivation into the lytic cycle. LMP1 is critical for EBV-infected cell activation, adhesion and survival, and is usually expressed in the malignant cells.

Applications

  • Application: FACS ; IHC

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
  • Shipping conditions: Dry ice

Related Tools

  • Related tools: Anti-EBV Latent Membrane Protein 1 [CS 1-4]

References

  • Niedobitek et al. 1995. Blood. 86(2):659-65. PMID: 7605996.
  • Heterogeneous expression of Epstein-Barr virus latent proteins in endemic Burkitt's lymphoma.

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