Cat. #152632
Anti-EBV Latent Membrane Protein 1 [LMPO24]
Cat. #: 152632
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: Epstein-Barr Virus, Latent Membrane Protein 1 (EBV-LMP1)
Class: Monoclonal
Application: FACS ; IHC
Reactivity: Virus
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Martin Rowe
Institute: University of Birmingham
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-EBV Latent Membrane Protein 1 [LMPO24]
- Research fields: Cancer;Cell biology;Cell signaling and signal transduction;Immunology;Microbiology
- Clone: LMPO24
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Strain: Balb/c
- Reactivity: Virus
- Host: Mouse
- Application: FACS ; IHC
- Description: Monoclonal antibody which can be used to investigate EBV latency and EBV-associated malignant cells. Background and Research Application EBV is a human herpesvirus that establishes a life-long persistence in the host. The virus infects the vast majority of the world's adult population and is well known for its association with a broad spectrum of benign and malignant diseases. These include infectious mononucleosis, Burkitt's lymphoma, nasopharyngeal carcinoma, and is causally associated with lymphoid and epithelial malignancies, including post-transplant lymphoproliferative disorders, Hodgkin's disease, anaplastic nasopharyngeal carcinoma and gastric carcinomas. This antibody is specific for latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV). LMP1 is a transforming protein that affects multiple cell signalling pathways and contributes to EBV-associated oncogenesis. This protein can be expressed in some states of EBV latency, and significant induction of full-length LMP1 is also observed frequently during virus reactivation into the lytic cycle. LMP1 is critical for EBV-infected cell activation, adhesion and survival, and is usually expressed in the malignant cells.
- Immunogen: Purified plasma membranes from LMP1 expressing insect cells infected with a recombinant LMP1 baculovirus
- Immunogen uniprot id: P03230
- Isotype: IgG1 kappa
- Recommended controls: EBV transformed lymphoblastoid cell lines
Target Details
- Target: Epstein-Barr Virus, Latent Membrane Protein 1 (EBV-LMP1)
- Tissue cell line specificity: EBV transformed lymphoblastoid cell lines
- Target background: Monoclonal antibody which can be used to investigate EBV latency and EBV-associated malignant cells. Background and Research Application EBV is a human herpesvirus that establishes a life-long persistence in the host. The virus infects the vast majority of the world's adult population and is well known for its association with a broad spectrum of benign and malignant diseases. These include infectious mononucleosis, Burkitt's lymphoma, nasopharyngeal carcinoma, and is causally associated with lymphoid and epithelial malignancies, including post-transplant lymphoproliferative disorders, Hodgkin's disease, anaplastic nasopharyngeal carcinoma and gastric carcinomas. This antibody is specific for latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV). LMP1 is a transforming protein that affects multiple cell signalling pathways and contributes to EBV-associated oncogenesis. This protein can be expressed in some states of EBV latency, and significant induction of full-length LMP1 is also observed frequently during virus reactivation into the lytic cycle. LMP1 is critical for EBV-infected cell activation, adhesion and survival, and is usually expressed in the malignant cells.
Applications
- Application: FACS ; IHC
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
- Shipping conditions: Dry ice
Related Tools
- Related tools: Anti-EBV Latent Membrane Protein 1 [CS 1-4]
References
- Niedobitek et al. 1995. Blood. 86(2):659-65. PMID: 7605996.
- Heterogeneous expression of Epstein-Barr virus latent proteins in endemic Burkitt's lymphoma.
